Anti-AXL Antibody

Cat: 10279-R003

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All AXL Reagents

Anti-AXL Antibody (Rabbit Monoclonal antibody) General Information

Product name
Anti-AXL Antibody
Species reactivity
Reacts with: Human
Human AXL
No cross-reactivity in ELISA with
Mouse AXL
Recombinant Human AXL protein (Catalog#10279-H08H)
This antibody was obtained from a rabbit immunized with purified, recombinant Human AXL (rh AXL; Catalog#10279-H08H; NP_068713.2; Met 1-Pro 449).
Monoclonal Rabbit IgG Clone #003
Protein A
0.2 μm filtered solution in PBS
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-AXL Antibody (Rabbit Monoclonal antibody) Validated Applications

Application Dilution Notes
ELISA 1:5000-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-AXL Antibody Alternative Names

Anti-ARK Antibody;Anti-JTK11 Antibody;Anti-Tyro7 Antibody;Anti-UFO Antibody

AXL Background Information

Axl receptor tyrosine kinase, together with Tyro3 and Mer, constitute the TAM family of receptor tyrosine kinases. In the nervous system, Axl and its ligand Growth-arrest-specific protein 6 (Gas6) are expressed on multiple cell types. Axl functions in dampening the immune response, regulating cytokine secretion, clearing apoptotic cells and debris, and maintaining cell survival. Axl is upregulated in various disease states, such as in the cuprizone toxicity-induced model of demyelination and in multiple sclerosis (MS) lesions, suggesting that it plays a role in disease pathogenesis. Axl expression correlates with poor prognosis in several cancers. Axl mediates multiple oncogenic phenotypes and activation of these RTKs constitutes a mechanism of chemoresistance in a variety of solid tumors. Axl contributes to cell survival, migration, invasion, metastasis and chemosensitivity justify further investigation of Axl as novel therapeutic targets in cancer. The receptor tyrosine kinase AXL is thought to play a role in metastasis. The soluble AXL receptor as a therapeutic candidate agent for treatment of metastatic ovarian cancer. GAS6/AXL targeting as an effective strategy for inhibition of metastatic tumor progression in vivo.
Full Name
AXL receptor tyrosine kinase
  • Weinger JG, et al. (2011) Loss of the receptor tyrosine kinase Axl leads to enhanced inflammation in the CNS and delayed removal of myelin debris during Experimental Autoimmune Encephalomyelitis. J Neuroinflammation. 8: 49.
  • Linger RM, et al. (2010) Taking aim at Mer and Axl receptor tyrosine kinases as novel therapeutic targets in solid tumors. Expert Opin Ther Targets. 14(10): 1073-90.
  • Cavet ME, et al. (2010) Gas6-Axl pathway: the role of redox-dependent association of Axl with nonmuscle myosin IIB. Hypertension. 56(1): 105-11.
  • Rankin EB, et al. (2010) AXL is an essential factor and therapeutic target for metastatic ovarian cancer. Cancer Res. 70(19): 7570-9.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-AXL Antibody Rabbit Polyclonal ELISA 50126-RP02
    Anti-AXL Antibody Rabbit Polyclonal ELISA 50126-T16
    Anti-AXL Antibody Rabbit Polyclonal ELISA 50126-RP01
    Anti-AXL Antibody Rabbit Monoclonal ELISA,ELISA(Cap) 50126-R109
    Anti-AXL Antibody Rabbit Monoclonal ELISA,ELISA(Det) 50126-R015
    Anti-AXL Antibody Rabbit Polyclonal ELISA 10279-RP02
    Anti-AXL Antibody Mouse Monoclonal FCM 10279-MM12
    Anti-AXL Antibody Rabbit Polyclonal ELISA 10279-T16
    Anti-AXL Antibody Rabbit Monoclonal FCM 10279-R101
    Anti-AXL Antibody (FITC) Rabbit Monoclonal FCM 10279-R101-F
    Anti-AXL Antibody Rabbit Polyclonal ELISA 10279-RP01
    Anti-AXL Antibody (PE) Mouse Monoclonal FCM 10279-MM12-P
    Anti-AXL Antibody Mouse Monoclonal ELISA 10279-MM17
    Anti-AXL Antibody Mouse Monoclonal ELISA 10279-MM05
    Anti-AXL Antibody (PE) Rabbit Monoclonal FCM 10279-R101-P
    Anti-AXL Antibody (FITC) Mouse Monoclonal FCM 10279-MM12-F
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