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ATP1B4 Antibody Datasheet
|Order or Inquire for ATP1B4 Antibody product||Quality antibodies||Antibody production services|
|Detection limit is 0.0195 ng/well in ELISA|
ATP1B4 Antibody Product Information
Recombinant Human ATP1B4 protein
|Antibody Type :||Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )|
Clone ID :
|Ig Type :||
|Formulation :||0.2 μm filtered solution in PBS with 5% trehalose|
This antibody was obtained from a rabbit immunized with purified, recombinant Human ATP1B4.
ATP1B4 Antibody Usage Guide
|Direct ELISA :||This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human ATP1B4. The detection limit for Human ATP1B4 is approximately 0.0195 ng/well.|
|Storage :||This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
ATP1B4 Antibody Related Products & Topics
ATP1B4 Antibody Background
ATP1B4 is a member of the X(+)/potassium ATPases subunit beta family. It is highly expressed in skeletal muscle and at a lower level in heart. ATP1B4 gene can be found in all vertebrate genomes sequenced to date. However, this gene has undergone a change in function in placental mammals compared to other species. Specifically, in fish, avian, and amphibian species, this gene encodes plasma membrane-bound beta-subunits of Na, K-ATPase. In placental mammals, the encoded protein interacts with the nuclear transcriptional coregulator SKIP and may be involved in the regulation of TGF-beta signaling. ATP1B4 may act as a transcriptional coregulator during muscle development through its interaction with SNW1. Na+, K+-ATPase is an important regulator of intracellular electrolyte levels in most mammalian cells. It is a Mg2+-dependent transport pump responsible for maintaining the low intracellular Na+:K+ ratio that is essential for cell homeostasis and physiological function. It catalyzes the active uptake of K+ and extrusion of Na+ at the expense of hydrolyzing ATP with a stoichiometry of 3 Na+ for 2 K+. ATP1B4 has lost its ancestral function as a Na,K-ATPase beta-subunit.
- Pestov NB. et al., 2007, Proc Natl Acad Sci. 104 (27): 11215-20.
- Kung AW. et al., 2006, Clin Endocrinol. 64 (2): 158-61.
- Gerhard DS. et al., 2004, Genome Res. 14 (10B): 2121-7.