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ATP1B4 Antibody, Rabbit MAb
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ATP1B4 Antibody, Rabbit MAb PDF Download

Catalog   Size (Price) Quantity In Stock Operation
13027-R108  

YES   
 

Primary antibody | Secondary antibody | Tag antibody | Isotype control antibody | Loading control antibody | Antibody Purification

ATP1B4 Antibody Datasheet

  Order or Inquire for ATP1B4 Antibody product Quality antibodies Antibody production services
  Detection limit is 0.0195 ng/well in ELISA
 

ATP1B4 Antibody Product Information

Immunogen :

Recombinant Human ATP1B4 protein

Antibody Type : Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )

Clone ID :

108

Ig Type :

Rabbit IgG

Formulation : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
Preparation :

This antibody was obtained from a rabbit immunized with purified, recombinant Human ATP1B4.

ATP1B4 Antibody Usage Guide

Specificity :

Human ATP1B4

Direct ELISA : This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human ATP1B4. The detection limit for Human ATP1B4 is approximately 0.0195 ng/well.
Storage : This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

ATP1B4 Antibody Related Products & Topics

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Proteins:

Antibodies:

ATP1B4 Antibody Background

ATP1B4 is a member of the X(+)/potassium ATPases subunit beta family. It is highly expressed in skeletal muscle and at a lower level in heart. ATP1B4 gene can be found in all vertebrate genomes sequenced to date. However, this gene has undergone a change in function in placental mammals compared to other species. Specifically, in fish, avian, and amphibian species, this gene encodes plasma membrane-bound beta-subunits of Na, K-ATPase. In placental mammals, the encoded protein interacts with the nuclear transcriptional coregulator SKIP and may be involved in the regulation of TGF-beta signaling. ATP1B4 may act as a transcriptional coregulator during muscle development through its interaction with SNW1. Na+, K+-ATPase is an important regulator of intracellular electrolyte levels in most mammalian cells. It is a Mg2+-dependent transport pump responsible for maintaining the low intracellular Na+:K+ ratio that is essential for cell homeostasis and physiological function. It catalyzes the active uptake of K+ and extrusion of Na+ at the expense of hydrolyzing ATP with a stoichiometry of 3 Na+ for 2 K+. ATP1B4 has lost its ancestral function as a Na,K-ATPase beta-subunit.

References

  1. Pestov NB. et al., 2007, Proc Natl Acad Sci. 104 (27): 11215-20.
  2. Kung AW. et al., 2006, Clin Endocrinol. 64 (2): 158-61.
  3. Gerhard DS. et al., 2004, Genome Res. 14 (10B): 2121-7.
 
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"