All ATP1B3 reagents are produced in house and quality controlled, including 2 ATP1B3 Antibody, 40 ATP1B3 Gene, 2 ATP1B3 qPCR. All ATP1B3 reagents are ready to use.
ATP1B3 antibodies are validated with different applications, which are WB, IHC-P.
ATP1B3 cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each ATP1B3 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
Enterovirus 71 (EV71) infection can cause severe diseases, and is becoming increasingly common in children. Human beta3 subunit of Na(+)/K(+)-ATPase (ATP1B3) protein was demonstrated to interact with the 3A protein of EV71. Although 3A protein had no effect on the expression of ATP1B3, EV71 infection resulted in elevated expression of ATP1B3 in RD cell line, both on messenger RNA (mRNA) and protein levels. And knockdown of ATP1B3 could significantly increase the replication of EV71, whereas overexpression of ATP1B3 significantly suppressed the replication of EV71 in RD cells. That the expression of ATP1B3 could induce the production of type-I interferons. ATP1B3 inhibit EV71 replication by enhancing the production of type-I interferons, which could act as a potential therapeutic target in EV71 infection.