All ATF2 reagents are produced in house and quality controlled, including 2 ATF2 Antibody, 30 ATF2 Gene, 1 ATF2 Lysate, 1 ATF2 Protein, 2 ATF2 qPCR. All ATF2 reagents are ready to use.
Recombinant ATF2 proteins are expressed by Baculovirus-Insect Cells with fusion tags as N-GST & His.
ATF2antibodies are validated with different applications, which are WB, ELISA, IHC-P, ICC/IF, IF.
ATF2cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each ATF2 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
Expression host: Baculovirus-Insect Cells
Activating transcription factor 2, also known as ATF2, is a member of the leucine zipper family of DNA-binding proteins that binds to the cAMP response element. Its activity is enhanced after phosphorylation by stress-activated protein kinases such as c-Jun N-terminal kinase and p38. ATF2 has been found to be a target of the JNK signal transduction pathway and mediate adenovirus E1A-inducible transcriptional activation. ATF2 is also been reported playing roles in TGF-β signaling pathway. It has been shown that the transcription factor ATF2 is bound by a hetero-oligomer of Smad3 and Smad4 upon TGF-β stimulation. Studies indicate that ATF-2 plays a central role in TGF-β signaling by acting as a common nuclear target of both Smad and TAK1 pathways.