ASGPR1 / ASGR1 Protein Price Inquiry ( Available Sizes )
ASGPR1 / ASGR1 Protein Product Information
||RP23-172M21.2, ASGPR1, Asgr, Asgr-1
||A DNA sequence encoding the extracellular domain (Ser 60-Asn 284) of mouse ASGPR1 (NP_033844.1) was expressed with a N-terminal polyhistidine tag
ASGPR1 / ASGR1 Protein QC Testing
||> 95 % as determined by SDS-PAGE
||< 1.0 EU per μg of the protein as determined by the LAL method.
||Samples are stable for up to twelve months from date of receipt at -70℃
|Predicted N terminal:
||The secreted recombinant mouse ASGR1 consists of 241 amino acids and has a calculated molecular mass of 28 kDa. As a result of glycosylation, the recombinant protein migrates as an approximately 40-45 kDa protein in SDS-PAGE under reducing conditions
||Lyophilized from sterile PBS , pH 7.4
ASGPR1 / ASGR1 Protein Usage Guide
||Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
||A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
ASGPR1 / ASGR1 Protein Related Products & Topics
ASGPR1 / ASGR1 Protein Description
Mouse asialoglycoprotein receptor (ASGPR) is a heterooligomeric receptor that is abundantly expressed on the sinusoidal surface of the hepatic plasma membrane. It is an endocytic receptor that rapidly binds and internalizes galactose-terminated glycoproteins (asialoglycoproteins or ASGP) from the circulation. The mouse ASGPR belongs to the long-form subfamily of the C-type/Ca2+ dependent lectin family. It is a complex of two noncovalently-linked and highly homologous subunits, a major 42 kDa glycoprotein ASGPR1(MHL-1) and a minor 51 kDa glycoprotein ASGR2 (MHL-2). ASGPR1 is synthesized as a type I I transmembrane protein that contains a cytosolic N-terminal domain, a single transmembrane segment, and an extracellular domain which contains two important structural regions. The first is a stalk domain that contributes to noncovalent oligomerization, and the second is a Ca2+-dependent carbohydrate binding domain at the very C-terminus that is unusually stabilized by three ions. The aa sequence of mouse ASGPR1 ECD is 89% and 79% identical to the ASGPR1 ECD of rat and human, respectively.
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