ASGPR1 Protein & Antibody (ASGR1)

Asialoglycoprotein Receptor 1

ASGPR1 Products

ASGPR1 Protein, Recombinant

Molecule	Species	Description	Cat. No
ASGPR1/ASGR1	Human	ASGPR1 / ASGR1 Protein,Recombinant	10773-H07H
ASGPR1/ASGR1	Mouse	ASGPR1 / ASGR1 Protein, Recombinant	50083-M07H

ASGPR1 Antibody

Molecule	Application	Description	Cat. No
Mouse ASGPR1/ASGR1	WB, ELISA	Rabbit Polyclonal Antibody	50083-RP01
Mouse ASGPR1/ASGR1	WB, ELISA	ASGPR1 / ASGR1 Antibody (Antigen Affinity Purified)	50083-RP02

ASGPR1 cDNA Clone

Molecule	Species	Description	Cat. No
ASGPR1/ASGR1	Human	Homo sapiens ASGPR1 cDNA Clone(NM_001671.3)	HG10773-M
ASGPR1/ASGR1	Mouse	Mus musculus ASGPR1 cDNA Clone	MG50083-M

ASGPR1 Alternative Names

ASGPR, ASGR1, CLEC4H1, Hs.12056 [Homo sapiens]

ASGPR1, Asgr1, Asgr, Asgr-1, RP23-172M21.2 [Mus musculus]

ASGPR1 Related Areas

Immunology>>Adhesion Molecule>>Lectin>>ASGPR1/ASGR1

ASGPR1 Background

The asialoglycoprotein receptor (ASGPR), an endocytotic cell surface receptor expressed by hepatocytes, is triggered by triantennary binding to galactose residues of macromolecules such as asialoorosomucoid (ASOR). ASGPR belongs to the long-form subfamily of the C-type/Ca2+ dependent lectin family. It is a complex of two noncovalently-linked and highly homologous subunits, a major 42 kDa glycoprotein ASGPR1(MHL-1) and a minor 51 kDa glycoprotein ASGR2 (MHL-2). ASGPR1 is synthesized as a type II transmembrane protein that contains a cytosolic N-terminal domain, a single transmembrane segment, and an extracellular domain which contains two important structural regions. The first is a stalk domain that contributes to noncovalent oligomerization, and the second is a Ca2+-dependent carbohydrate binding domain at the very C-terminus that is unusually stabilized by three ions. The research regarded that ASGPR1 could be targeted for anti- hepatitis B virus (HBV) drug development.

ASGPR1 Related Studies

1. Yang J, et al. (2006) Antisense oligonucleotides targeted against asialoglycoprotein receptor 1 block human hepatitis B virus replication. J Viral Hepat. 13(3): 158-65.
2. Li Y, et al. (2008) Targeted delivery of macromolecular drugs: asialoglycoprotein receptor (ASGPR) expression by selected hepatoma cell lines used in antiviral drug development. Curr Drug Deliv. 5(4): 299-302.