Anti-Asialoglycoprotein Receptor 1 Antibody

Cat: 50083-RP01
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Anti-Asialoglycoprotein Receptor 1 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-Asialoglycoprotein Receptor 1 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Mouse
Specificity
Mouse Asialoglycoprotein Receptor 1
Immunogen
Recombinant Mouse ASGR1 protein (Catalog#50083-M07H)
Preparation
Produced in rabbits immunized with purified, recombinant Mouse ASGR1 extracellular domain (rM ASGR1; Catalog#50083-M07H; NP_033844.1; Ser 60-Asn 284). Total IgG was purified by Protein A affinity chromatography .
Source
Polyclonal Rabbit IgG
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-Asialoglycoprotein Receptor 1 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-Asialoglycoprotein Receptor 1 Antibody Alternative Names
Anti-ASGPR1 Antibody;Anti-Asgr Antibody;Anti-Asgr-1 Antibody;Anti-HL-1 Antibody
Asialoglycoprotein Receptor 1 Background Information

The asialoglycoprotein receptor (ASGPR), an endocytotic cell surface receptor expressed by hepatocytes, is triggered by triantennary binding to galactose residues of macromolecules such as asialoorosomucoid (ASOR). ASGPR belongs to the long-form subfamily of the C-type/Ca2+ dependent lectin family. It is a complex of two noncovalently-linked and highly homologous subunits, a major 42 kDa glycoprotein ASGPR1(MHL-1) and a minor 51 kDa glycoprotein ASGR2 (MHL-2). ASGPR1 is synthesized as a type II transmembrane protein that contains a cytosolic N-terminal domain, a single transmembrane segment, and an extracellular domain which contains two important structural regions. The first is a stalk domain that contributes to noncovalent oligomerization, and the second is a Ca2+-dependent carbohydrate binding domain at the very C-terminus that is unusually stabilized by three ions. The research regarded that ASGPR1 could be targeted for anti- hepatitis B virus (HBV) drug development.

Full Name
asialoglycoprotein receptor 1
References
  • Yang J, et al. (2006) Antisense oligonucleotides targeted against asialoglycoprotein receptor 1 block human hepatitis B virus replication. J Viral Hepat. 13(3): 158-65.
  • Li Y, et al. (2008) Targeted delivery of macromolecular drugs: asialoglycoprotein receptor (ASGPR) expression by selected hepatoma cell lines used in antiviral drug development. Curr Drug Deliv. 5(4): 299-302.
  • Product Description Host Clonality Application Catalog# (PDF)
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    Anti-Asialoglycoprotein Receptor 1 Antibody Mouse Monoclonal IHC-P 10773-MM02
    Anti-Asialoglycoprotein Receptor 1 Antibody Rabbit Polyclonal WB,ELISA,IHC-P,IP 10773-RP02
    Anti-Asialoglycoprotein Receptor 1 Antibody Rabbit Monoclonal IHC-P 10773-R011
    Anti-Asialoglycoprotein Receptor 1 Antibody Rabbit Monoclonal ELISA(Det) 10773-R024
    Anti-Asialoglycoprotein Receptor 1 Antibody Rabbit Polyclonal ELISA 10773-RP01
    Anti-Asialoglycoprotein Receptor 1 Antibody Rabbit Monoclonal WB,ELISA(Cap),IP 10773-R021
    Anti-Asialoglycoprotein Receptor 1 Antibody Rabbit Monoclonal ELISA 10773-R023
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