ASAM Protein & Antibody (ACAM, CLMP)

Adipocyte-Specific Adhesion Molecule (Adipocyte Adhesion Molecule, CAR-Like Membrane Protein)

ASAM Products

ASAM Protein, Recombinant

Molecule	Species	Description	Cat. No
ASAM	Human	ASAM Protein, Recombinant	10794-H08H
ASAM	Mouse	ASAM Protein, Recombinant	50553-M08H

  10794-H08H: When 4 x 10⁴ cells/well are added to human ASAM coated plates (30 µg/mL, 100 µL/well), approximately 25 %-50 % will adhere after one hour at 37 ℃. Measured by the ability of the immobilized protein to support the adhesion of the HUVEC human umbilical vein endothelial cell line.

  50553-M08H: When 4 x 10⁴ cells/well are added to mouse ASAM coated plates (30 µg/mL, 100 µL/well), approximately > 40 % will adhere after one hour at 37 ℃. Measured by the ability of the immobilized protein to support the adhesion of the HUVEC human umbilical vein endothelial cell line.

ASAM Antibody

Molecule	Application	Description	Cat. No
Human ASAM	ELISA	ASAM/ACAM/CLMP Antibody, Mouse Mab	10794-MM05
Human ASAM	ELISA	Rabbit Polyclonal Antibody	10794-RP01
Human ASAM	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	10794-RP02
Mouse ASAM	WB, ELISA	Rabbit Polyclonal Antibody	50553-R030
Mouse ASAM	WB, ELISA	Rabbit Polyclonal Antibody	50553-R001
Mouse ASAM	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	50553-RP02

ASAM cDNA Clone

Molecule	Species	Description	Cat. No
Rat ASAM	Rat	ASAM/ACAM/CLMP cDNA Clone	RG80219-G

ASAM Related Areas

Immunology>>Adhesion Molecule>>Cell Adhesion Molecule (IgSF CAM)>>ASAM

ASAM Alternative Names

ASAM, ACAM, CLMP, FLJ22415 [Homo sapiens]

ASAM Background

Adipocyte-specific adhesion molecule (ASAM), also known as ACAM and CLMP, is a type I transmembrane protein and a member of the CTX (cortical thymocyte marker in Xenopus) family within the immunoglobulin superfamily. ASAM protein is highly expressed in the small intestine and placenta, and is found at intermediate levels in the heart, skeletal muscle, colon, spleen, kidney, and lung, and appears in low levels in the liver and peripheral blood leukocytes as well. ASAM is a transmembrane component of tight junctions in epithelial cells that can mediate cell aggregation and regulate transepithelial resistance across polarized epithelial cells. In addition, its expression is strongly correlated with white adipose tissue (WAT) mass of human and rodents with obesity.

ASAM Related Studies

1. Eguchi J, et al. (2005) Identification of adipocyte adhesion molecule (ACAM), a novel CTX gene family, implicated in adipocyte maturation and development of obesity. Biochem J. 387(Pt 2): 343-53.
2. Sze KL, et al. (2008) Expression of CLMP, a novel tight junction protein, is mediated via the interaction of GATA with the Kruppel family proteins, KLF4 and Sp1, in mouse TM4 Sertoli cells. J Cell Physiol. 214(2): 334-44.
3. Sze KL, et al. (2008) Post-transcriptional regulation of CLMP mRNA is controlled by tristetraprolin in response to TNFalpha via c-Jun N-terminal kinase signalling. Biochem J. 410(3): 575-83.