ASAH2 Protein & Antibody

N-acylsphingosine amidohydrolase 2

ASAH2 Protein & Antibody

ASAH2 Protein, Recombinant

Molecule	Species	Description	Cat. No
ASAH2	Mouse	ASAH2 Protein, Recombinant	50006-M07H

  50006-M07H: The specific activity is 800-2000 U / mg. Measured by its ability to hydrolysis acetylcholine.

ASAH2 Antibody

Molecule	Application	Description	Cat. No
Mouse ASAH2	ELISA	Rabbit Monoclonal Antibody	50006-R004
Mouse ASAH2	ELISA	Rabbit Polyclonal Antibody	50006-RP01
Mouse ASAH2	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	50006-RP02

ASAH2 Related Areas

Enzyme>>Lipid Metabolism Enzymes>>ASAH2

Cardiovascular>>Lipid Metabolism>>Lipid Metabolism Enzymes>>ASAH2

ASAH2 Alternative Names

ASAH2, BCDase, HNAC1, MGC129777, NCDase [Homo sapiens]

Asah2, AI585898 [Mus musculus]

ASAH2 Background

ASAH2 (N-acylsphingosine amidohydrolase 2), also known as neutral ceramidase, is a type II integral membrane protein that can be cleaved to produce a soluble secreted protein. The enzyme is abundant in the brush border membranes of the intestine, and also expressed in several tissues such as kidney, brain and liver. The primary structure of ASAH2/neutral ceramidase is highly conserved from bacteria to humans, however, there is a clear difference in the molecular architecture. The murine ASAH2 possesses ‘amucin box’, a Ser/Thr/Pro-rich domain glycosylated with O-glycans which is necessary to retain the enzyme on the plasma membrane as a type II integral protein. The major physiological function of ASAH2/neutral ceramidase is the metabolism of dietary sphingolipids, and thus plays a role in the generation of messenger molecules such as sphingosine and sphingosine 1-phosphate.

ASAH2 Related Studies

1. Tani M, et al. (2000) Molecular cloning of the full-length cDNA encoding mouse neutral ceramidase. A novel but highly conserved gene family of neutral/alkaline ceramidases. J Biol Chem. 275(15): 11229-34.
2. Franzen R, et al. (2002) Nitric oxide induces neutral ceramidase degradation by the ubiquitin/proteasome complex in renal mesangial cell cultures. FEBS Lett. 532(3): 441-4.
3. Kono M, et al. (2006) Neutral ceramidase encoded by the Asah2 gene is essential for the intestinal degradation of sphingolipids. J Biol Chem. 281(11): 7324-31.