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ARG1/Arginase 1  Protein, Antibody, ELISA Kit, cDNA Clone

Expression host: Human Cells  
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10 µg 
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Expression host: Human Cells  
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ARG1/Arginase 1 Related Area

ARG1/Arginase 1 Related Pathways

    ARG1/Arginase 1 Summary & Protein Information

    ARG1/Arginase 1 Background

    Gene Summary: Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exist (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type I isoform encoded by this ARG1 gene, is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle. Inherited deficiency of this enzyme results in argininemia, an autosomal recessive disorder characterized by hyperammonemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
    General information above from NCBI
    Catalytic activity: L-arginine + H(2)O = L-ornithine + urea.
    Cofactor: Name=Mn(2+); Xref=ChEBI:CHEBI:29035; ; Note=Binds 2 manganese ions per subunit.;
    Subunit structure: Homotrimer. {ECO:0000269|PubMed:16141327, ECO:0000269|PubMed:17469833, ECO:0000269|PubMed:17562323, ECO:0000269|PubMed:18802628, ECO:0000269|PubMed:2241902}.
    Subcellular location: Cytoplasm {ECO:0000269|PubMed:16141327}.
    Induction: By arginine or homoarginine.
    Involvement in disease: DISEASE: Argininemia (ARGIN) [MIM:207800]: A rare autosomal recessive disorder of the urea cycle. Arginine is elevated in the blood and cerebrospinal fluid, and periodic hyperammonemia occurs. Clinical manifestations include developmental delay, seizures, mental retardation, hypotonia, ataxia and progressive spastic quadriplegia. {ECO:0000269|PubMed:1463019, ECO:0000269|PubMed:22959135, ECO:0000269|PubMed:23859858, ECO:0000269|PubMed:7649538}. Note=The disease is caused by mutations affecting the gene represented in this entry.
    Sequence similarity: Belongs to the arginase family. {ECO:0000255|PROSITE-ProRule:PRU00742}.
    General information above from UniProt

    Arginase is the focal enzyme of the urea cycle hydrolysing L-arginine to urea and L-ornithine. Emerging studies have identified arginase in the vasculature and have implicated this enzyme in the regulation of nitric oxide (NO) synthesis and the development of vascular disease. Arginase also redirects the metabolism of L-arginine to L-ornithine and the formation of polyamines and L-proline, which are essential for smooth muscle cell growth and collagen synthesis. Arginase is encoded by two recently discovered genes (Arginase I and Arginase II). In most mammals, Arginase 1 (ARG1) also known as Arginase, liver, which functions in the urea cycle, and is located primarily in the cytoplasm of the liver. The second isozyme, Arginase II, has been implicated in the regulation of the arginine/ornithine concentrations in the cell. It is located in mitochondria of several tissues in the body, with most abundance in the kidney and prostate. It may be found at lower levels in macrophages, lactating mammary glands, and brain.

    ARG1/Arginase 1 Alternative Name

    ARG1,arginase,Arginase 1,liver,OTTHUMP00000017209,OTTHUMP00000017211,OTTHUMP00000017210, [human]
    AI,AI256583,Arg1,Arg-1,arginase,Arginase 1,liver,PGIF, [mouse]

    ARG1/Arginase 1 Related Studies

  • Durante W, et al. (2007) Arginase: a critical regulator of nitric oxide synthesis and vascular function. Clin Exp Pharmacol Physiol. 34(9): 906-11.
  • Waddington SN. (2002) Arginase in glomerulonephritis. Kidney Int. 61(3): 876-81.
  • Morris SM. (2002). Regulation of enzymes of the urea cycle and arginine metabolism. Annual review of nutrition. 22 (1): 87-105.