ARG1 / Arginase 1 Protein & Antibody

Arginase, liver

ARG1 / Arginase 1 Products

ARG1 / Arginase 1 Protein, Recombinant

Molecule	Species	Description	Cat. No
ARG1/Arginase 1	Human	ARG1/Arginase 1 Protein, Recombinant	11558-H08H

ARG1 / Arginase 1 Antibody

Molecule	Application	Description	Cat. No
Human ARG1 /Arginase 1	WB, ELISA	ARG1 / Arginase 1 Antibody	11558-RP01
Human ARG1 /Arginase 1	WB, ELISA	ARG1 / Arginase 1 Antibody (Antigen Affinity Purified)	11558-RP02

ARG1 / Arginase 1 cDNA Clone

Molecule	Species	Description	Cat. No
ARG1/Arginase 1	Human	ARG1/Arginase 1 cDNA Clone / ORF Clone	HG11558-M

ARG1 / Arginase 1 Related Areas

Enzyme>>Other>>ARG1/Arginase 1

ARG1 / Arginase 1 Alternative Names

ARG1, Arginase 1, arginase, liver, OTTHUMP00000017209, OTTHUMP00000017210, OTTHUMP00000017211 [Homo sapiens]

Arg1, Arginase 1, arginase, liver, AI, AI256583, Arg-1, PGIF [Mus musculus]

ARG1 / Arginase 1 Background

Arginase is the focal enzyme of the urea cycle hydrolysing L-arginine to urea and L-ornithine. Emerging studies have identified arginase in the vasculature and have implicated this enzyme in the regulation of nitric oxide (NO) synthesis and the development of vascular disease. Arginase also redirects the metabolism of L-arginine to L-ornithine and the formation of polyamines and L-proline, which are essential for smooth muscle cell growth and collagen synthesis. Arginase is encoded by two recently discovered genes (Arginase I and Arginase II). In most mammals, Arginase 1 (ARG1) also known as Arginase, liver, which functions in the urea cycle, and is located primarily in the cytoplasm of the liver. The second isozyme, Arginase II, has been implicated in the regulation of the arginine/ornithine concentrations in the cell. It is located in mitochondria of several tissues in the body, with most abundance in the kidney and prostate. It may be found at lower levels in macrophages, lactating mammary glands, and brain.

ARG1 / Arginase 1 Related Studies

1. Durante W, et al. (2007) Arginase: a critical regulator of nitric oxide synthesis and vascular function. Clin Exp Pharmacol Physiol. 34(9): 906-11.
2. Waddington SN. (2002) Arginase in glomerulonephritis. Kidney Int. 61(3): 876-81.
3. Morris SM. (2002). Regulation of enzymes of the urea cycle and arginine metabolism. Annual review of nutrition. 22 (1): 87–105.