|Datasheet||Specific References||Reviews||Related Products||Protocols|
|ORF Clone of amyloid beta (A4) precursor-like protein 1 DNA.|
|Identical with the Gene Bank Ref. ID sequence.|
|Whatman FTA elute card (Cat: WB120410) contains 5-10 μg of plasmid.|
|The Whatman FTA elute card can be stored at room temperature for three months under dry condition.|
The pGEM-T is 3kb in length, and contains the amplicin resistance gene, conferring selection of the plasmid in E. coli, and the ori site which is the bacterial origin of replication. The plasmid has multiple cloning sites as shown below. The coding sequence was inserted by TA cloning. Many E. coli strains are suitable for the propagation of this vector including JM109, DH5α and TOP10.
The coding sequence can be easily obtained by digesting the vector with proper restriction enzyme(s). The coding sequence can also be amplified by PCR with M13 primers, or primer pair SP6 and T7.
|Human APLP1 Gene cDNA Clone (full-length ORF Clone), expression ready, FLAG-tagged||HG13716-G-F|
|Human APLP1 Gene cDNA Clone (full-length ORF Clone), expression ready, His-tagged||HG13716-G-H|
|Human APLP1 Gene cDNA Clone (full-length ORF Clone), expression ready, Myc-tagged||HG13716-G-M|
|Human APLP1 Gene cDNA Clone (full-length ORF Clone), expression ready, untagged||HG13716-G-N|
|Human APLP1 Gene cDNA Clone (full-length ORF Clone), expression ready, HA-tagged||HG13716-G-Y|
|Product name||Product name|
APLP1, also known as amyloid-like protein 1, is a member of the highly conserved amyloid precursor protein gene family. APLP1 is a membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor protein cleavage. APLP1, together with APLP2, are important modulators of glucose and insulin homeostasis. APLP1 may also play a role in synaptic maturation during cortical development. Alternatively spliced transcript variants encoding different isoforms have been described. APLP1 also is a mammalian homologue of amyloid precursor protein (APP). APP is a type I membrane protein that is genetically linked to Alzheimer's disease.