APEX1 / APEx / Ref-1 protein

APEX nuclease (multifunctional DNA repair enzyme) 1

APEX1 Products

APEX1 Protein, Recombinant

Molecule	Species	Description	Cat. No
APEX1	Human	APEX1 / AP / APEx / Ref-1 Protein, Recombinant	12367-H07E

APEX1 Related Areas

Cancer>>Cell Cycle >>DNA Repair>> APEX1

Enzyme>>Oxidoreductase>> APEX1

APEX1 Alternative Names

APE, APE1, APEN, APEX, APX, HAP1, REF1 [Homo sapiens]

APE, Apex, HAP1, Ref-1 [Mus musculus]

APEX1 Background

The enzyme is known to be a redox factor (Ref-1) stimulating DNA binding activity of AP-1 binding proteins such as Fos and Jun as well as a multifunctional DNA repair enzyme having 5' AP endonuclease, DNA 3' repair diesterase, 3'-5' exonuclease and DNA 3'-phosphatase activities.Although Apex mRNA was expressed ubiquitously, the levels varied significantly, suggesting organ- or tissue-specific expression of the Apex gene. The highest level was observed in the testis, relatively high levels in the thymus, spleen, kidney and brain, and the lowest level in the liver in rats. However, the present results suggested that APEX/Ref-1 gene product can interact with AP-1 binding proteins in brain, especially in the hippocampal formation, to regulate some brain functions by redox-activation.

APEX1 Related Studies

1. Ono Y, et al. (1995) Developmental expression of APEX nuclease, a multifunctional DNA repair enzyme, in mouse brains. Brain Res Dev Brain Res.86 (1-2): 1-6.
2. Tan Y, et al. (1996) cDNA cloning of rat major AP endonuclease (APEX nuclease) and analyses of its mRNA expression in rat tissues. Acta Med Okayama. 50 (1): 53-60.
3. Yao M, et al. (1999) Genomic structure of the rat major AP endonuclease gene (Apex) with an adjacent putative O-sialoglycoprotease gene (Prsmg1/Gcpl1) and a processed Apex pseudogene (Apexp1). Acta Med Okayama. 53 (6): 245-52.