Serum Amyloid P cDNA ORF Clone in Cloning Vector, Human

Cat: HG13610-G
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Serum Amyloid P cDNA ORF Clone in Cloning Vector, Human General Information
Gene
Species
Human
NCBI Ref Seq
RefSeq ORF Size
672 bp
Sequence Description
Identical with the Gene Bank Ref. ID sequence.
Description
Full length Clone DNA of Human amyloid P component, serum.
Plasmid
Vector
pGEM-T Vector
Sequencing Primers
SP6 and T7 or M13-47 and RV-M
Quality Control
The plasmid is confirmed by full-length sequencing.
Screening
Antibiotic in E.coli
Ampicillin
Storage & Shipping
Shipping
Each tube contains lyophilized plasmid.
Storage
The lyophilized plasmid can be stored at ambient temperature for three months.
Serum Amyloid P cDNA ORF Neucleotide Sequence and Amino Acid Sequence Information

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

Serum Amyloid P cDNA ORF Clone in Cloning Vector, Human Alternative Names
HEL-S-92n cDNA ORF Clone, Human;PTX2 cDNA ORF Clone, Human;SAP cDNA ORF Clone, Human
Serum Amyloid P Background Information

Serum amyloid P component (SAP) is the identical serum form of amyloid P component (AP), a highly preserved plasma protein named for its ubiquitous presence in amyloid deposits. As a normal plasma protein first identified as the pentagonal constituent of in vivo pathological deposits called "amyloid". Serum amyloid P component represents another member of the pentraxin family, a highly conserved group of molecules that may play a role in innate immunity. SAP is a key negative regulator for innate immune responses to DNA and may be partly responsible for the insufficient immune responses after DNA vaccinations in humans. SAP suppression may be a novel strategy for improving efficacy of human DNA vaccines and requires further clinical investigations.

Full Name
amyloid P component, serum
References
  • Wang Y, et al. (2011) Human serum amyloid P functions as a negative regulator of the innate and adaptive immune responses to DNA vaccines. J Immunol. 186(5): 2860-70.
  • Hawkins PN. (2002) Serum amyloid P component scintigraphy for diagnosis and monitoring amyloidosis. Curr Opin Nephrol Hypertens. 11(6): 649-55.
  • Noursadeghi M, et al. (2000) Role of serum amyloid P component in bacterial infection: protection of the host or protection of the pathogen. Proc Natl Acad Sci U S A. 97: 14584-9.
  • de Haas CJ. (1999) New insights into the role of serum amyloid P component, a novel lipopolysaccharide-binding protein. FEMS Immunol Med Microbiol. 26(3-4): 197-202.
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    Serum Amyloid P cDNA ORF Clone, Human, Related Products

    Product Name Catalog#(PDF)
    Serum Amyloid P cDNA ORF Clone, Human, untagged HG13610-UT
    Serum Amyloid P Lentiviral cDNA ORF Clone, Human, C-GFPSpark® tag HG13610-ACGLN
    Serum Amyloid P cDNA ORF Clone, Human, C-GFPSpark® tag HG13610-ACG
    Serum Amyloid P cDNA ORF Clone, Human, C-OFPSpark® tag HG13610-ACR
    Serum Amyloid P cDNA ORF Clone, Human, C-DDK (Flag®) tag HG13610-CF
    Serum Amyloid P cDNA ORF Clone, Human, N-DDK (Flag®) tag HG13610-NF
    Serum Amyloid P cDNA ORF Clone, Human, C-His tag HG13610-CH
    Serum Amyloid P cDNA ORF Clone, Human, N-His tag HG13610-NH
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    Serum Amyloid P cDNA ORF Clone, Human, N-HA tag HG13610-NY
    Serum Amyloid P cDNA ORF Clone, Human, C-Myc tag HG13610-CM
    Serum Amyloid P cDNA ORF Clone, Human, N-Myc tag HG13610-NM
    Serum Amyloid P qPCR Primer Pairs, Human HP102295
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