ANGPTL5 Protein (GST Tag)

Angiopoietin-related Protein 5 ( ANGPTL5 ) Protein Datasheet

ANGPTL5 Protein Price Information

500ug:  Inquiring Price;               ≥1mg Bulk:  Inquiring Price

ANGPTL5 Protein Product Information

• Synonym: ANGPTL5
• Protein Construction: A DNA sequence encoding the mature form of human ANGPTL5 (NP_835228.2) (Asn 26-Lys 388) was fused with the GST tag at the N-terminus.
• Source: Human
• Expression Host: Baculovirus-Insect cells

ANGPTL5 Protein QC Testing

• Purity: > 90 % as determined by SDS-PAGE.
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
• Stability: Samples are stable for up to twelve months from date of receipt at -70℃
• Predicted N terminal: Met
• Molecular Mass: The recombinant human ANGPTL5/GST chimera consists of 588 amino acids and predicts a molecular mass of 68 kDa as estimated in SDS-PAGE under reducing conditions.
• Formulation: Lyophilized from sterile 50mM Tris, 100mM Nacl, pH 8, 0.5mM GSH, 0.5mM PMSF, 0.5mM EDTA
• SDS-PAGE:

ANGPTL5 Protein Usage Guide

• Storage: Store it under sterile conditions at -70℃ upon receiving. Recommend to aliquot the protein into smaller quantities for optimal storage. Avoid repeated freeze-thaw cycles.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

ANGPTL5 Protein Description

Angiopoietin-related protein 5, also known as, Angiopoietin-like 5 and ANGPTL5, is a member of the Angiopoietin family. Angiopoietin family consists of ANGPT1, ANGPT2, ANGPT4, ANGPTL1 (ANGPT3), ANGPTL2, ANGPTL3 (ANGPT5), ANGPTL4, ANGPTL5, ANGPTL6 and ANGPTL7. They are secreted proteins possessing an amino-terminal coiled-coil domain and a carboxyl-terminal fibrinogen-like domain and are known as angiogenic factors. They act as growth factors that promote angiogenesis, the formation of blood vessels from pre-existing blood vessels. Like other members of the angiopoietin family, ANGPTL5 protein also has an N-terminal cleavable signal peptide, a predicted coiled-coil domain, and a fibrinogen-like domain. ANGPTL5 is mainly expressed in adult human heart. Loss of function mutations of ANGPTL3, ANGPTL4, and ANGPTL5 are associated with a low triglyceride concentration. They are regulators of lipoprotein metabolism in humans. Inhibition of these ANGPTLs will be useful for dyslipidemia to prevent cardiovascular disease.

ANGPTL5 Protein Related Products & Topics

• ANGPTL5 Protein Related Areas:
• Proteins:
• Antibodies:

References

1. Zeng, L. et al., 2003, J Hum Genet. 48 (3): 159-62.

2. Katoh, Y. et al., 2006, Int J Mol Med. 17 (6): 1145-9.

3. Niki, D. et al., 2009, Dev Growth Differ. 51 (9): 821-32.

4. Miida, T. et al., 2009, Curr Opin Lipidol.