ANGPTL5 Protein

Angiopoietin-Like 5

ANGPTL5 Products

ANGPTL5 Protein, Recombinant

Molecule	Species	Description	Cat. No
ANGPTL5	Human	ANGPTL5 Protein, Recombinant, With GST Tag	11094-H09B

ANGPTL5 Alternative Names

ANGPTL5, angiopoietin-like 5, fibrinogen-like

ANGPTL5Background

The angiopoietins are protein growth factors that promote angiogenesis, the formation of blood vessels from pre-existing blood vessels. There are now four identified angiopoietins: Ang1, Ang2, Ang3, Ang4. In addition, there are a number of proteins that are closely related to angiopoietins (ANGPTL2, ANGPTL3, ANGPTL4, ANGPTL5, ANGPTL6, ANGPTL7). Angiopoietin-like 5 (ANGPTL5) is mainly expressed in adult heart. Like other members of the angiopoietin family, ANGPTL5-deduced protein also has an N-terminal cleavable signal peptide, a predicted coiled-coil domain, and a fibrinogen-like domain. ANGPTL5 are regulators of lipoprotein metabolism in humans. ANGPTL5 plays nonredundant roles in TG metabolism, and multiple alleles at these loci cumulatively contribute to variability in plasma TG levels in humans.

ANGPTL5 Related Studies

1. Miida T, et al. (2010) Impacts of angiopoietin-like proteins on lipoprotein metabolism and cardiovascular events. Curr Opin Lipidol. 21(1): 70-5.
2. Romeo S, et al. (2009) Rare loss-of-function mutations in ANGPTL family members contribute to plasma triglyceride levels in humans. J Clin Invest. 119(1): 70-9.
3. Zeng L, et al. (2003) Identification of a novel human angiopoietin-like gene expressed mainly in heart. J Hum Genet. 48(3): 159-62.