Angiopoietin-1 (Protein|Antibody|cDNA Clone|ELISA Kit)

All Angiopoietin-1 reagents are produced in house and quality controlled, including 41 Angiopoietin-1 Gene, 2 Angiopoietin-1 Lysate, 2 Angiopoietin-1 Protein, 2 Angiopoietin-1 qPCR. All Angiopoietin-1 reagents are ready to use.

Recombinant Angiopoietin-1 proteins are expressed by HEK293 Cells with fusion tags as N-His.

Angiopoietin-1 cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each Angiopoietin-1 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.

Angiopoietin-1 Protein (2)

Species

Angiopoietin-1 Protein, Mouse, Recombinant (His Tag)

50300-M07H

Expression host: HEK293 Cells

Mouse Angiopoietin 1 / ANG1 / ANGPT1 Protein 11551

Angiopoietin-1 Protein, Cynomolgus, Recombinant (His Tag)

90025-C07H

Expression host: HEK293 Cells

Cynomolgus Angiopoietin 1 / ANG1 / ANGPT1 Protein 12740
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Angiopoietin-1 cDNA Clone (41)

Rhesus
Human
Mouse

Angiopoietin-1 qPCR Primer (2)

Angiopoietin-1 Lysate (2)

The angiopoietin (ANGPT)-TIE2/TEK signaling pathway is essential for blood and lymphatic vascular homeostasis. ANGPT1 is a potent TIE2 activator, whereas ANGPT2 functions as a context-dependent agonist/antagonist. In disease, ANGPT2-mediated inhibition of TIE2 in blood vessels is linked to vascular leak, inflammation, and metastasis. Primary congenital glaucoma (PCG) is a leading cause of blindness in children worldwide and is caused by developmental defects in 2 aqueous humor outflow structures, Schlemm's canal (SC) and the trabecular meshwork. We previously identified loss-of-function mutations in the angiopoietin (ANGPT) receptor TEK in families with PCG and showed that ANGPT/TEK signaling is essential for SC development. A role for the major ANGPT ligands in the development of the aqueous outflow pathway. We determined that ANGPT1 is essential for SC development, and that Angpt1-knockout mice form a severely hypomorphic canal with elevated intraocular pressure. By linking ANGPT1 with PCG, these results highlight the importance of ANGPT/TEK signaling in glaucoma pathogenesis and identify a candidate target for therapeutic development.
Protein
Gene
qPCR
Lysate
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