ALOX5AP / FLAP Protein

Arachidonate 5-Lipoxygenase-Activating Protein

ALOX5AP / FLAP Products

ALOX5AP / FLAP Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat No
ALOX5A/PFLAP	Human	ALOX5AP/FLAP Protein, Recombinant	11623-H08B

ALOX5AP / FLAP cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat No
ALOX5A/PFLAP	Human	Homo sapiens ALOX5AP/FLAP cDNA Clone	HG11623-M

ALOX5AP / FLAP Related Areas

Enzyme>>Lipid Metabolism Enzymes>>ALOX5A/PFLAP

Cardiovascular>>Lipid Metabolism>>Lipid Metabolism Enzymes>>ALOX5A/PFLAP

ALOX5AP / FLAP Alternative Names

ALOX5AP, FLAP [Homo sapiens]

Alox5ap, Flap [Mus musculus]

ALOX5AP / FLAP Background

Arachidonate 5-Lipoxygenase-Activating Protein (ALOX5AP), also known as FLAP, belongs to the MAPEG family. ALOX5AP/FLAP is an essential partner of 5-LO for this process. The FLAP (ALOX5AP) gene has been linked to risk for myocardial infarction, stroke and restenosis, reigniting pharmaceutical interest in this target. It had been found that ALOX5AP/FLAP is a key enzyme in leukotriene formation, in both human pulmonary microvascular endothelial cells and a transformed human brain endothelial cell line. In addition, the protein FLAP has recently been identified as an emerging target in metabolic disease. In fact, FLAP is overexpressed in the adipose tissue of patients and experimental animals with obesity and insulin resistance.

ALOX5AP / FLAP Related Studies

1. Gonsalves CS, et al. (2010) Hypoxia-mediated expression of 5-lipoxygenase-activating protein involves HIF-1alpha and NF-kappaB and microRNAs 135a and 199a-5p. J Immunol. 184(7): 3878-88.
2. Zintzaras E, et al. (2009) Variants of the arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene and risk of stroke: a HuGE gene-disease association review and meta-analysis. Am J Epidemiol. 169(5): 523-32.
3. Evans JF, et al. (2008) What's all the FLAP about?: 5-lipoxygenase-activating protein inhibitors for inflammatory diseases. Trends Pharmacol Sci. 29(2): 72-8.
4. Bäck M, et al. (2007) 5-Lipoxygenase-activating protein: a potential link between innate and adaptive immunity in atherosclerosis and adipose tissue inflammation. Circ Res. 100: 946–9.
5. Kaaman M, et al. (2006) ALOX5AP expression, but not gene haplotypes, is associated with obesity and insulin resistance. Int J Obes (Lond.). 30: 447–52.