Anti-ACVR1B Antibody

Cat: 10583-MM01
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Anti-ACVR1B Antibody (Mouse Monoclonal antibody) General Information
Product name
Anti-ACVR1B Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human ACVR1B
No cross-reactivity in ELISA with Human ACTRII / ACVR2 / ACVR2A Human ACVR2B / ACTRIIB
Immunogen
Recombinant Human ALK4 protein (Catalog#10583-H08H)
Preparation
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human ALK4 extracellular domain (rh ALK4; Catalog#10583-H08H; NP_004293.1; Met 1-Glu 126). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Source
Monoclonal Mouse IgG1 Clone #4E1C1F12
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-ACVR1B Antibody (Mouse Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-ACVR1B Antibody Alternative Names
Anti-ACTRIB Antibody;Anti-ACVRLK4 Antibody;Anti-ALK4 Antibody;Anti-SKR2 Antibody
ACVR1B Background Information

ALK-4 (Activin Receptor-Like Kinase 4) or ACVR1B (Activin A Receptor, type 1B), belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family, and TGFB receptor subfamily. ALK-4/ACVR1B acts as a transducer of activin or activin like ligands signals. Activin binds to either ACVR2A or ACVR2B and then forms a complex with ACVR1B. The known type II activin receptors include ActRII and ActRIIB, while the main type I activin receptor in mammalian cells is ALK-4 (ActRIB). In the presence of activin, type II and type I receptors form complexes whereby the type II receptors activate ALK-4 through phosphorylation. The activated ALK-4, in turn, transduces signals downstream by phosphorylation of its effectors, such as Smads, to regulate gene expression and affect cellular phenotype. ALK-4/ACVR1B is an important regulator of vertebrate development, with roles in mesoderm induction, primitive streak formation, gastrulation, dorsoanterior patterning, and left-right axis determination.

Full Name
activin A receptor, type IB
References
  • Chen Y, et al. (2005) Developmental analysis of activin-like kinase receptor-4 (ALK4) expression in Xenopus laevis. 232(2): 393-8.
  • J. Massagu. (1998) TGF- SIGNAL TRANSDUCTION. Annual Review of Biochemistry. 67: 753-91.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-ACVR1B Antibody Rabbit Polyclonal WB,ELISA 10583-T48
    info info
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