ALK-4 Protein & Antibody (ACVR1B)

Activin Receptor-Like Kinase 4 (Activin A Receptor, type 1B)

ALK-4 Protein Products

ALK-4 Protein, Recombinant

Molecule	Species	Description	Cat. No
ALK-4/ACVR1B	Human	ALK-4/ACVR1B/Fc Protein, Recombinant	10583-H03H
ALK-4/ACVR1B	Human	ALK-4/ACVR1B Protein, Recombinant	10583-H08H

  10583-H03H: Immobilized human TDGF1 at 2 µg/ml (100 µl/well) can bind human ALK-4 with a linear range of 0.0068-0.16 µg/ml. Measured by its binding ability in a functional ELISA.

  10583-H08H: Immobilized human TDGF1 at 2 µg/ml (100 µl/well) can bind human ALK-4 with a linear range of 0.032-4 µg/ml. Measured by its binding ability in a functional ELISA.

ALK-4 Antibody

Molecule	Application	Description	Cat. No
Human ALK-4/ACVR1B	WB, ELISA	ALK-4/ACVR1B Antibody, Mouse MAb	10583-MM01

ALK-4 cDNA Clone

Molecule	Species	Description	Cat. No
ALK-4/ACVR1B	Human	Homo sapiens ALK-4/ACVR1B cDNA Clone(NM_004302.3)	HG10583-M
ALK-4/ACVR1B	Rat	Rat ALK-4/ACVR1B cDNA Clone	RG80137-G

ALK-4 Related Areas

Cancer>>Growth Factor & Receptor>>TGF-beta Superfamily>>Activin/Inhibitin>>ALK-4/ACVR1B

Immunology>>Cytokine & Receptor>>TGF-beta Superfamily>>TGF-beta Superfamily Receptors>>ALK-4/ACVR1B

ALK-4 Alternative Names

ALK-4, ALK4, ACVR1B, ACTRIB, ACVRLK4, SKR2 [Homo sapiens]

ALK-4, Alk4, Acvr1b, ActRIB, ActR-IB, Acvrlk4, SKR2, 6820432J04 [Mus musculus]

ALK-4 Background

ALK-4 (Activin Receptor-Like Kinase 4) or ACVR1B (Activin A Receptor, type 1B), belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family, and TGFB receptor subfamily. ALK-4/ACVR1B acts as a transducer of activin or activin like ligands signals. Activin binds to either ACVR2A or ACVR2B and then forms a complex with ACVR1B. The known type II activin receptors include ActRII and ActRIIB, while the main type I activin receptor in mammalian cells is ALK-4 (ActRIB). In the presence of activin, type II and type I receptors form complexes whereby the type II receptors activate ALK-4 through phosphorylation. The activated ALK-4, in turn, transduces signals downstream by phosphorylation of its effectors, such as Smads, to regulate gene expression and affect cellular phenotype. ALK-4/ACVR1B is an important regulator of vertebrate development, with roles in mesoderm induction, primitive streak formation, gastrulation, dorsoanterior patterning, and left-right axis determination.

ALK-4 Related Studies

1. Chen Y, et al. (2005) Developmental analysis of activin-like kinase receptor-4 (ALK4) expression in Xenopus laevis. 232(2): 393-8.
2. J. Massagué. (1998) TGF-β SIGNAL TRANSDUCTION. Annual Review of Biochemistry. 67: 753-91.