ALK-3 Protein & Antibody (BMPR1A, CD292)

Activin receptor-Like Kinase 3/Bone Morphogenetic Protein Receptor, type IA

ALK-3 Products

ALK-3 Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
ALK-3/BMPRIA/CD292	Human	ALK-3/BMPRIA/Fc Protein, Recombinant	10446-H03H
ALK-3/BMPRIA/CD292	Human	ALK-3/BMPRIA Protein, Recombinant	10446-H08H
ALK-3/BMPRIA/CD292	Mouse	ALK-3/BMPRIA/Fc Protein, Recombinant	50078-M03H
ALK-3/BMPRIA/CD292	Mouse	ALK-3/BMPRIA Protein, Recombinant	50078-M08H

10446-H03H: The ED50 for this effect is typically 0.17 µg/mL in the presence of 50 ng/mL of recombinant human BMP4. Measured by its ability to inhibit BMP4 induced activity in MC3T3-E1 Mouse osteoblastic cells.

50078-M03H: The ED50 for this effect is typically 0.18 µg/mL in the presence of 50 ng/mL of recombinant human BMP4. Measured by its ability to inhibit BMP4 induced activity in MC3T3-E1 Mouse osteoblastic cells.

ALK-3 Antibody

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Mouse ALK-3/BMPRIA/CD292	WB, ELISA	ALK-3/BMPRIA/CD292 Antibody, Rabbit PAb	50078-RP01
Mouse ALK-3/BMPRIA/CD292	WB, ELISA	ALK-3/BMPRIA/CD292 Antibody, Rabbit PAb (Antigen Affinity Purified)	50078-RP02

ALK-3 cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
ALK-3/BMPRIA/CD292	Human	Human ALK-3 / BMPRIA cDNA Clone / ORF Clone	HG10446-M
ALK-3/BMPRIA/CD292	Human	Human ALK-3 / BMPRIA ORF Expression Clone, untagged	HG10446-M-N
ALK-3/BMPRIA/CD292	Mouse	Mouse ALK-3 / BMPRIA cDNA Clone / ORF Clone	MG50078-M
ALK-3/BMPRIA/CD292	Canine	Canine BMPR1A Gene cDNA Clone / ORF Clone	DG70051-G
ALK-3/BMPRIA/CD292	Rat	Rat BMPR1A cDNA Clone / ORF Clone	RG80138-G
ALK-3/BMPRIA/CD292	Rat	Rat BMPR1A ORF Expression Clone, untagged	RG80138-G-N
ALK-3/BMPRIA/CD292	Cynomolgus	Cynomolgus monkey BMPR1A cDNA Clone / ORF Clone	CG90064-G

ALK-3 Alternative Names

ALK-3, BMPR1A, CD292, ACVRLK3, ALK3, 10q23del, SKR5 [Homo sapiens]

ALK-3, BMPR-IA, Bmpr1a, ALK3, 1110037I22Rik, AU045487 [Mus musculus]

ALK-3 Related Areas

Neuroscience>>Axon Guidance>>BMP Family>>ALK-3/BMPRIA/CD292

Stem Cell>>Mesenchymal Stem Cell (MSC)>>Mesenchymal Stem Cell Marker>>ALK-3/BMPRIA/CD292

Cancer>>Growth Factor & Receptor>>TGF-beta Superfamily>>BMP Family>>ALK-3/BMPRIA/CD292

Immunology>>Cytokine & Receptor>>TGF-beta Superfamily>>TGF-beta Superfamily Receptors>>ALK-3/BMPRIA/CD292

Immunology>>Cluster of Differentiation>>T Cell CD Antigen>>Other>>ALK-3/BMPRIA/CD292

ALK-3 Background

Activin receptor-Like Kinase 3 (ALK-3), also known as Bone Morphogenetic Protein Receptor, type IA (BMPR1A), is a type I receptor for bone morphogenetic proteins (BMPs) which belong to the transforming growth factor beta (TGF-β) superfamily. The BMP receptors form a subfamily of transmembrane serine/threonine kinases including the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. ALK-3/BMPR1A is expressed in the epithelium during branching morphogenesis. Deletion of BMPR1A in the epithelium with an Sftpc-cre transgene leads to dramatic defects in lung development. ALK-3 and ALK-6 share a high degree of homology, yet possess distinct signaling roles. The transforming growth factor (TGF)-beta type III receptor (TbetaRIII) enhanced both ALK-3 and ALK-6 signaling. TbetaRIII associated with ALK-3 primarily through their extracellular domains, whereas its interaction with ALK-6 required both the extracellular and cytoplasmic domains. ALK-3 plays an essential role in the formation of embryonic ventral abdominal wall, and abrogation of BMP signaling activity due to gene mutations in its signaling components could be one of the underlying causes of omphalocele at birth. The type IA BMP receptor, ALK-3 was specifically required at mid-gestation for normal development of the trabeculae, compact myocardium, interventricular septum, and endocardial cushion. Cardiac muscle lacking ALK-3 was specifically deficient in expressing TGFbeta2, an established paracrine mediator of cushion morphogenesis. Hence, ALK-3 is essential, beyond just the egg cylinder stage, for myocyte-dependent functions and signals in cardiac organogenesis.

ALK-3 Related Studies

Gaussin V, et al. (2002) Endocardial cushion and myocardial defects after cardiac myocyte-specific conditional deletion of the bone morphogenetic protein receptor ALK3. Proc Natl Acad Sci U S A. 99(5): 2878-83.
Eblaghie MC, et al. (2006) Evidence that autocrine signaling through Bmpr1a regulates the proliferation, survival and morphogenetic behavior of distal lung epithelial cells. Dev Biol. 291(1): 67-82.
Sun J, et al. (2007) Deficient Alk3-mediated BMP signaling causes prenatal omphalocele-like defect. Biochem Biophys Res Commun. 360(1): 238-43.
Lee NY, et al. (2009) The transforming growth factor-beta type III receptor mediates distinct subcellular trafficking and downstream signaling of activin-like kinase (ALK)3 and ALK6 receptors. Mol Biol Cell. 20(20): 4362-70.