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Product Catalog
> ALK-2 Protein (ACVR1 Protein) ALK-2 Protein (ACVR1 Protein)
Activin receptor-Like Kinase 2/Activin Receptor, type I
ALK-2 Products
ALK-2 Protein, Recombinant
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| ALK-2/ACVR1 | Human | ALK-2/ACVR1/Fc Protein, Recombinant |
10227-H03H |
| ALK-2/ACVR1 | Human | ALK-2 / ACVR1 / ALK2 Protein, Recombinant | 10227-H08B |
| ALK-2/ACVR1 | Mouse | ALK-2/ACVR1/Fc Protein, Recombinant |
50297-M03H |
10227-H03H: Measure by its ability to bind with human BMP2 in a functional ELISA.
50297-M03H: Measure by its ability to bind with human BMP2 in a functional ELISA.
ALK-2 cDNA Clone
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| ALK-2/ACVR1 | Human | ALK-2 / ACVR1 transcript variant 2 cDNA Clone / ORF Clone | HG10227-M |
| ALK-2/ACVR1 | Mouse | ALK-2/ACVR1 cDNA Clone / ORF Clone | MG50297-M |
| ALK-2/ACVR1 | Rat | ACVR1 cDNA Clone / ORF Clone | RG80118-G |
| ALK-2/ACVR1 | Cynomolgus | ACVR1 cDNA Clone / ORF Clone | KG90058-G |
ALK-2 Alternative Names
ALK2, ACVR1, ACTRI, ACVR1A, ACVRLK2, FOP, SKR1, TSRI [Homo sapiens]
Alk-2, Acvr1, ALK2, ActR-I, ActRIA, Acvr, Acvrlk2, Alk8, RP23-100B18.4, D330013D15Rik, SKR1, Tsk7L [Mus musculus]
ALK-2 Related Areas
Cancer>>Growth Factor & Receptor>>TGF-beta Superfamily>>Activin/Inhibitin>>ALK-2/ACVR1
Immunology>>Cytokine & Receptor>>TGF-beta Superfamily>>TGF-beta Superfamily Receptors>>ALK-2/ACVR1
ALK-2 Related Products
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! |
| Inhibin beta A/INHBA | Human | Inhibin beta A/INHBA Protein, Recombinant |
| Inhibin beta B/INHBB | Human | Inhibin beta B/INHBB Protein, Recombinant |
| ACVR2A | Human | ACVR2A/Fc Protein, Recombinant |
| ACVR2B | Human | ACVR2B/Fc Protein, Recombinant |
| ACVR2B | Human | ACVR2B Protein, Recombinant |
| ACVR2B | Mouse | ACVR2B/Fc Protein, Recombinant |
| ACVR2B | Mouse | ACVR2B Protein, Recombinant |
| FSTL1/Follistatin Like 1 | Human | FSTL1 Protein, Recombinant |
| FLRG/FSTL3 | Mouse | FLRG/FSTL3 Protein, Recombinant |
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! |
| Inhibin alpha/INHA | Human | Homo sapiens Inhibin alpha/INHA cDNA Clone(NM_002191.2) |
| Inhibin beta A/INHBA | Human | Homo sapiens Inhibin beta A/INHBA cDNA Clone(NM_002192.2) |
| Inhibin beta B/INHBB | Human | Homo sapiens Inhibin beta B/INHBB cDNA Clone(NM_002193.2) |
| Inhibin beta C/INHBC | Human | Homo sapiens Inhibin beta C/INHBC cDNA Clone(NM_005538.2) |
| Inhibin beta E/INHBE | Human | Homo sapiens Inhibin beta E/INHBE cDNA Clone(NM_031479.3) |
| ALK-4/ACVR1B | Human | Homo sapiens ALK-4/ACVR1B cDNA Clone(NM_004302.3) |
| ACVR2A | Human | Homo sapiens ACVR2A cDNA Clone(NM_001616.3) |
| ACVR2B | Human | Homo sapiens ACVR2B cDNA Clone(NM_001106.3) |
| Follistatin | Human | Homo sapiens Follistatin cDNA Clone(NM_013409.1) |
| FSTL1/Follistatin Like 1 | Human | Homo sapiens FSTL1 cDNA Clone(NM_007085.4) |
ALK-2 Background
ALK-2, also termed as ACVR1, was initially identified as an activin type I receptor because of its ability to bind activin in concert with ActRII or ActRIIB. ALK-2 is also identified as a BMP type I receptor. It has been demonstrated that ALK-2 forms complex with either the BMP-2/7-bound BMPR-II or ACVR2A /ACVR2B. ALK-1 and ALK-2 presenting in the yeast Saccharomyces cerevisiae are two haspin homologues. Both ALK-1 and ALK-2 exhibit a weak auto-kinase activity in vitro, and are phosphoproteins in vivo. ALK-1 and ALK-2 levels peak in mitosis and late-S/G2. Control of protein stability plays a major role in ALK-2 regulation. The half-life of ALK-2 is particularly short in G1. Overexpression of ALK-2, but not of ALK-1, causes a mitotic arrest, which is correlated to the kinase activity of the protein. This suggests a role for ALK-2 in the control of mitosis. Endoglin is phosphorylated on cytosolic domain threonine residues by the TGF-beta type I receptors ALK-2 and ALK-5 in prostate cancer cells. Endoglin did not inhibit cell migration in the presence of constitutively active ALK-2. Defects in ALK-2 are a cause of fibrodysplasia ossificans progressiva (FOP).
ALK-2 Related Studies
- Armes NA,et al. (1997) The ALK-2 and ALK-4 activin receptors transduce distinct mesoderm-inducing signals during early Xenopus development but do not co-operate to establish thresholds. Development 124(19): 3797-804.
- Armes NA, et al. (1999) A short loop on the ALK-2 and ALK-4 activin receptors regulates signaling specificity but cannot account for all their effects on early Xenopus development. J Biol Chem. 274(12):7929-35.
- Kawai S, et al. (2000) Mouse smad8 phosphorylation downstream of BMP receptors ALK-2, ALK-3, and ALK-6 induces its association with Smad4 and transcriptional activity.Biochem Biophys Res Commun. 271(3):682-7.
- Deng Y, et al. (2009) Efficient highly selective synthesis of methyl 2-(ethynyl)alk-2(E)-enoates and 2-(1'-chlorovinyl)alk-2(Z)-enoates from 2-(methoxycarbonyl)-2,3-allenols. Organic letters 11(10):2169-72.
