- EGFR Signaling Pathway
- TGF-beta Signaling
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- Cytokine Signaling
>Human Cell Expressed
>Cynomolgus ALK-2 / ACVR1 / ALK2 Protein (Fc Tag)
|Catalog||Size (Price)||Quantity||In Stock||Operation|
Activin A receptor, type I Protein Datasheet
ALK-2 / ACVR1 / ALK2 Protein Price Inquiry ( Available Sizes )
- ≥1mg Bulk: Inquiring Price
ALK-2 / ACVR1 / ALK2 Protein Product Information
A DNA sequence encoding the cynomolgus ACVR1 (F7A9J8) (Met1-Glu123) was expressed with the Fc region of human IgG1 at the C-terminus.
|Expression Host:||Human Cells|
ALK-2 / ACVR1 / ALK2 Protein QC Testing
|Purity:||(75.3+22.3)% as determined by SDS-PAGE||SDS-PAGE:
ALK-2 / ACVR1 / ALK2 protein
|Endotoxin:||< 1.0 EU per μg of the protein as determined by the LAL method|
|Stability:||Samples are stable for up to twelve months from date of receipt at -70℃|
|Predicted N terminal:||Asp 23|
The recombinant cynomolgus ACVR1 is a disulfide-linked homodimer. The reduced monomer comprises 342 amino acids and has a calculated molecular mass of 38.2 KDa.The apparent molecular mass of the protein is approximately 44 and 37 KDa respectively in SDS-PAGE.
|Formulation:||Lyophilized from sterile PBS, pH 7.4.
ALK-2 / ACVR1 / ALK2 Protein Usage Guide
|Storage:||Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.|
|Reconstitution:||A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.|
ALK-2 / ACVR1 / ALK2 Protein Related Products & Topics
|Molecule||Species||Description //For Detailed Info. and Price------CLICK!||Cat. No|
|ALK-2/ACVR1||Human||ALK-2/ACVR1/Fc Protein, Recombinant||10227-H03H|
|ALK-2/ACVR1||Human||ALK-2 / ACVR1 / ALK2 Protein, Recombinant||10227-H08B|
|ALK-2/ACVR1||Mouse||ALK-2/ACVR1/Fc Protein, Recombinant||50297-M03H|
|ALK-2/ACVR1||Rat||ALK-2 / ACVR1 / ALK2 Protein, Recombinant||80118-R02H|
|ALK-2/ACVR1||Cynomolgus||ALK-2 / ACVR1 / ALK2 Protein, Recombinant||90058-C02H|
ALK-2 / ACVR1 / ALK2 Protein Description
Cytokines and hormones belonging to the transforming growth factor beta (TGFβ) superfamily such as the activin, anti-müllerian hormone (AMH), bone morphogenetic proteins (BMPs), and Nodal, are involved in a variety of physiological processes including growth, cell differentiation, homeostasis, osteogenesis, and apoptosis. They initiate signaling through heteromeric complexes of a type I and a type I I serine/threonine kinase receptor. The two type receptors are type I transmembrane proteins and are distinguished by the presence of a glycine/serine-rich juxta-membrane domain found in the type I receptors. Type II receptors are required for binding ligands and recruitment of type I receptors which then form stable complexes, and type I receptors are essential for signaling transduction. ALK2, also termed as ACVR1, ActRI, SKR1, was initially identified as an activin type I receptor because of its ability to bind activin in concert with ActRII or IIB. In addition, ALK2 is also identified as a BMP type I receptor. ACVR1 has been demonstrated to form complex with either the BMP-2/7-bound BMPR-II or ACVR2A/ACVR2B and transduce signals to downstream components R-SMADs. Recombinant soluble ALK2 does not bind activin. Mutations in this gene are associated with fibrodysplasia ossificans progressive.
- Attisano L. et al., 1993, Cell. 75: 671-80.
- Ten Dijke P. et al., 1994, Science. 264: 101-4.
- Macias-Silva M. et al., 1998, J Biol Chem. 273: 25628-36.
- Shore EM. et al., 2006, Nature Genetics. 38: 525-7.
- Renlund N. et al., 2007, J Endocrinology. 195: 95-103.
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