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ALDH3A1 Protein, Antibody, ELISA Kit, cDNA Clone

ALDH3A1 Related Areas

ALDH3A1 Related Pathways

ALDH3A1 Related Product

    ALDH3A1 Summary & Protein Information

    ALDH3A1 Background

    Gene Summary: Aldehyde dehydrogenases oxidize various aldehydes to the corresponding acids. They are involved in the detoxification of alcohol-derived acetaldehyde and in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. The enzyme encoded by this ALDH3A1 gene forms a cytoplasmic homodimer that preferentially oxidizes aromatic and medium-chain (6 carbons or more) saturated and unsaturated aldehyde substrates. ALDH3A1 is thought to promote resistance to UV and 4-hydroxy-2-nonenal-induced oxidative damage in the cornea. The ALDH3A1 gene is located within the Smith-Magenis syndrome region on chromosome 17. Multiple alternatively spliced variants, encoding the same protein, have been identified.
    General information above from NCBI
    Catalytic activity: An aldehyde + NAD(P)(+) + H(2)O = a carboxylate + NAD(P)H.
    Subunit structure: Homodimer.
    Subcellular location: Cytoplasm.
    Tissue specificity: High levels in stomach, esophagus and lung; low level in the liver and kidney.
    Sequence similarity: Belongs to the aldehyde dehydrogenase family.C
    General information above from UniProt

    ALDH3A1 Alternative Name

    ALDH3,ALDH3A1,ALDHIII,MGC10406, [human]
    Aldh3,Aldh3a1,RP23-55I2.1,Ahd4,Ahd-4,Aldh, [mouse]

    ALDH3A1 Related Studies

  • Pappa A, et al. (2003) Human aldehyde dehydrogenase 3A1 (ALDH3A1): biochemical characterization and immunohistochemical localization in the cornea. Biochem J. 376(3): 615-23.
  • Estey T, et al. (2007) ALDH3A1: a corneal crystallin with diverse functions. Experimental Eye Research. 84(1):3-12.
  • Pappa A, et al. (2003) Aldh3a1 protects human corneal epithelial cells from ultraviolet- and 4-hydroxy-2-nonenal-induced oxidative damage. Free Radical Biology and Medicine. 34(9):1178-89.
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