Gene Summary: Aldehyde dehydrogenases oxidize various aldehydes to the corresponding acids. They are involved in the detoxification of alcohol-derived acetaldehyde and in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. The enzyme encoded by this ALDH3A1 gene forms a cytoplasmic homodimer that preferentially oxidizes aromatic and medium-chain (6 carbons or more) saturated and unsaturated aldehyde substrates. ALDH3A1 is thought to promote resistance to UV and 4-hydroxy-2-nonenal-induced oxidative damage in the cornea. The ALDH3A1 gene is located within the Smith-Magenis syndrome region on chromosome 17. Multiple alternatively spliced variants, encoding the same protein, have been identified.General information above from NCBI
Catalytic activity: An aldehyde + NAD(P)(+) + H(2)O = a carboxylate + NAD(P)H.
Subunit structure: Homodimer.
Subcellular location: Cytoplasm.
Tissue specificity: High levels in stomach, esophagus and lung; low level in the liver and kidney.
Sequence similarity: Belongs to the aldehyde dehydrogenase family.C