ALDH1A3 (RALDH3)

Aldehyde dehydrogenase 1 family, member A3 (ALDH1A3), also known as Retinaldehyde dehydrogenase 3 (RALDH3), which belongs to the aldehyde dehydrogenase family. ALDH1A3 is a novel Cancer stem cell (CSC) marker with potential clinical prognostic applicability, and demonstrates a clear correlation between CSC prevalence and the development of metastatic breast cancer. The retinoic acid (RA) biosynthesis enzyme aldehyde dehydrogenase 1A3 (ALDH1A3) is a putative androgen-responsive gene in human prostate cancer epithelial (LNCaP) cells. The RA biosynthesis enzyme ALDH1A3 is androgen responsive and (ii) DHT up-regulation of ALDH1A3 can increase the oxidation of retinal to RA and indirectly affect RA bioactivity and metabolism.

ALDH1A3 (RALDH3) Related Areas

Alcohol Metabolism>>ALDH1A3/RALDH3

ALDH1A3 (RALDH3) Alternative Names

ALDH1A3, RALDH3, RALDH-3, ALDH1A6, ALDH6 [Homo sapiens]

Aldh1a3, RALDH3, RALDH-3, ALDH6, RALDH3, V1 [Mus musculus]

Summaries for ALDH1A3 (RALDH3)

Entrez Gene summary for ALDH1A3:

Aldehyde dehydrogenase isozymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. The enzyme encoded by this ALDH1A3 gene uses retinal as a substrate, either in a free or cellular retinol-binding protein form. [provided by RefSeq, Jul 2008]

Wikipedia summary for ALDH1A3:

Aldehyde dehydrogenase 1 family, member A3 also known as ALDH1A3 is an enzyme that in humans is encoded by the ALDH1A3 gene.

Human ALDH1A3 (RALDH3) Protein General Information

 

• Protein names: Aldehyde dehydrogenase family 1 member A3
• Sequence length: 512 AA.
• Catalytic activity: An aldehyde + NAD(P)+ + H2O = a carboxylate + NAD(P)H.
• Sequence similarities: ALDH1A3 belongs to the aldehyde dehydrogenase family.
• Pathway: Cofactor metabolism; retinol metabolism.
• Subcellular location: Cytoplasm
• Tissue specificity: ALDH1A3 is expressed at low levels in many tissues and at higher levels in salivary gland, stomach, and kidney.

General information above from UniProt

Function for ALDH1A3 (RALDH3) Protein

UniProtKB:

ALDH1A3 recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. ALDH1A3 seems to be the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system

Genatlas:

• ALDH1A3 is detoxication of aldehydes generated by alcohol metabolism and lipid peroxidation
• ALDH1A3 plays a role in the second step in ethanol utilization
• its transcriptional activation is involved in regulation of the retinoic acid metabolism in the epidermis
• ALDH1A3 decreases potentially insulin secretion from pancreatic beta-cells, whereas it increases glucagon secretion from pancreatic alpha-cells

Homology for human ALDH1A3 (RALDH3)

• homolog to murine Aldh1a3
• ortholog to Drosophila CG3752
• ortholog to C.elegans K04F1.15
• paralog to ALDH1A1
• paralog to ALDH1A2