Aldehyde dehydrogenase 1 family, member A3 (ALDH1A3), also known as Retinaldehyde dehydrogenase 3 (RALDH3), which belongs to the aldehyde dehydrogenase family. ALDH1A3 is a novel Cancer stem cell (CSC) marker with potential clinical prognostic applicability, and demonstrates a clear correlation between CSC prevalence and the development of metastatic breast cancer. The retinoic acid (RA) biosynthesis enzyme aldehyde dehydrogenase 1A3 (ALDH1A3) is a putative androgen-responsive gene in human prostate cancer epithelial (LNCaP) cells. The RA biosynthesis enzyme ALDH1A3 is androgen responsive and (ii) DHT up-regulation of ALDH1A3 can increase the oxidation of retinal to RA and indirectly affect RA bioactivity and metabolism.
ALDH1A3 ELISA Pair sets
ALDH1A3 cDNA Clones
ALDH1A3, RALDH3, RALDH-3, ALDH1A6, ALDH6 [Homo sapiens]
Aldh1a3, RALDH3, RALDH-3, ALDH6, RALDH3, V1 [Mus musculus]
Entrez Gene summary for ALDH1A3:
Aldehyde dehydrogenase isozymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. The enzyme encoded by this ALDH1A3 gene uses retinal as a substrate, either in a free or cellular retinol-binding protein form. [provided by RefSeq, Jul 2008]
Wikipedia summary for ALDH1A3:
Aldehyde dehydrogenase 1 family, member A3 also known as ALDH1A3 is an enzyme that in humans is encoded by the ALDH1A3 gene.
Aldehyde dehydrogenase family 1 member A3
An aldehyde + NAD(P)+ + H2O = a carboxylate + NAD(P)H.
ALDH1A3 belongs to the aldehyde dehydrogenase family.
Cofactor metabolism; retinol metabolism.
ALDH1A3 is expressed at low levels in many tissues and at higher levels in salivary gland, stomach, and kidney.
General information above from UniProt
ALDH1A3 recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. ALDH1A3 seems to be the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system
- ALDH1A3 is detoxication of aldehydes generated by alcohol metabolism and lipid peroxidation
- ALDH1A3 plays a role in the second step in ethanol utilization
- its transcriptional activation is involved in regulation of the retinoic acid metabolism in the epidermis
- ALDH1A3 decreases potentially insulin secretion from pancreatic beta-cells, whereas it increases glucagon secretion from pancreatic alpha-cells
- homolog to murine Aldh1a3
- ortholog to Drosophila CG3752
- ortholog to C.elegans K04F1.15
- paralog to ALDH1A1
- paralog to ALDH1A2