ALDH1A3 / RALDH3 Protein

Aldehyde dehydrogenase 1 family, member A3 / Retinaldehyde dehydrogenase 3

ALDH1A3 / RALDH3 Products

ALDH1A3 / RALDH3 Protein, Recombinant

Molecule	Species	Description	Cat. No
ALDH1A3/RALDH3	Human	ALDH1A3/RALDH3 Protein, Recombinant	11636-H07E

ALDH1A3 / RALDH3 cDNA Clone

Molecule	Species	Description	Cat. No
ALDH1A3/RALDH3	Human	Homo sapiens ALDH1A3/RALDH3 cDNA Clone	HG11636-M

ALDH1A3 / RALDH3 Related Areas

Alcohol Metabolism>>ALDH1A3/RALDH3

ALDH1A3 / RALDH3 Alternative Names

ALDH1A3, RALDH3, RALDH-3, ALDH1A6, ALDH6 [Homo sapiens]

Aldh1a3, RALDH3, RALDH-3, ALDH6, RALDH3, V1 [Mus musculus]

ALDH1A3 / RALDH3 Background

Aldehyde dehydrogenase 1 family, member A3 (ALDH1A3), also known as Retinaldehyde dehydrogenase 3 (RALDH3), which belongs to the aldehyde dehydrogenase family. ALDH1A3 is a novel Cancer stem cell (CSC) marker with potential clinical prognostic applicability, and demonstrates a clear correlation between CSC prevalence and the development of metastatic breast cancer. The retinoic acid (RA) biosynthesis enzyme aldehyde dehydrogenase 1A3 (ALDH1A3) is a putative androgen-responsive gene in human prostate cancer epithelial (LNCaP) cells. The RA biosynthesis enzyme ALDH1A3 is androgen responsive and (ii) DHT up-regulation of ALDH1A3 can increase the oxidation of retinal to RA and indirectly affect RA bioactivity and metabolism.

ALDH1A3 / RALDH3 Related Studies

1. Marcato P, et al. (2011) Aldehyde dehydrogenase activity of breast cancer stem cells is primarily due to isoform ALDH1A3 and its expression is predictive of metastasis. Stem Cells. 29(1)32-45.
2. Trasino SE, et al. (2007) Androgen regulation of aldehyde dehydrogenase 1A3 (ALDH1A3) in the androgen-responsive human prostate cancer cell line LNCaP. Exp Biol Med (Maywood). 232(6): 762-71.