ALDH1A1 / ALDH1 Protein & Antibody

Aldehyde dehydrogenase 1 family, member A1

ALDH1A1 / ALDH1 Products

ALDH1A1 / ALDH1 Protein, Recombinant

Molecule	Species	Description	Cat. No
ALDH1A1/ALDH1	Human	ALDH1A1/ALDH1 Protein, Recombinant	11388-H07E

ALDH1A1 / ALDH1 Antibody

Molecule	Application	Description	Cat. No
Human ALDH1A1/ALDH1	WB, ELISA	ALDH1A1/ALDH1 Antibody, Rabbit PAb	11388-RP01
Human ALDH1A1/ALDH1	WB, ELISA	ALDH1A1/ALDH1 Antibody, Rabbit PAb (Antigen Affinity Purified)	11388-RP02

ALDH1A1 / ALDH1 cDNA Clone

Molecule	Species	Description	Cat. No
ALDH1A1/ALDH1	Human	Homo sapiens ALDH1A1/ALDH1 cDNA Clone	HG11388-M

ALDH1A1 / ALDH1 Related Areas

Alcohol Metabolism>>ALDH1A1/ALDH1

ALDH1A1 / ALDH1 Alternative Names

ALDH1A1, ALDH1, RALDH1, ALDH-E1, ALHDII, RP11-151D14.2, ALDC, ALDH11, MGC2318, PUMB1, ALDH class 1, RALDH 1 [Homo sapiens]

Aldh1a 1, Aldh1, Raldh1, ALDH-E1, ALHDII, Aldh1a2, Ahd-2, Ahd2, E1 [Mus musculus]

ALDH1A1 / ALDH1 Background

Aldehyde dehydrogenase 1 family, member A1 (ALDH1A1), also known as Aldehyde dehydrogenase 1 (ALDH1), or Retinaldehyde Dehydrogenase 1 (RALDH1), is an enzyme that is expressed at high levels in stem cells and that has been suggested to regulate stem cell function. The retinaldehyde dehydrogenase (RALDH) subfamily of ALDHs, composed of ALDH1A1, ALDH1A2, ALDH1A3, and ALDH8A1, regulate development by catalyzing retinoic acid biosynthesis. The ALDH1A1 protein belongs to the aldehyde dehydrogenases family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. ALDH1A1 also belongs to the group of corneal crystallins that help maintain the transparency of the cornea. Increased ALDH1A1 activity has been found in the stem cell populations of leukemia and some solid tumors. In tumor specimens, increased ALDH1A1 immunopositivity was found not only in secretory type cancer epithelial cells but also in neuroendocrine tumor populations. ALDH1 has been identified as a reliable marker of breast cancer stem cells. ALDH1 expression in primary cancer is an independent prognostic factor in node-positive breast cancer patients. ALDH1A1 plays a key role in normal hematopoiesis, and as a TLX1 transcriptional target, ALDH1A1 may contribute to the ability of this homeoprotein to alter cell fate and induce tumor growth.

ALDH1A1 / ALDH1 Related Studies

1. Li T, et al. (2010). ALDH1A1 is a marker for malignant prostate stem cells and predictor of prostate cancer patients' outcome. Lab Invest. 90(2): 234-44.
2. Levi BP, et al. (2009) Aldehyde dehydrogenase 1a1 is dispensable for stem cell function in the mouse hematopoietic and nervous systems. Blood. 113(8): 1670-80.
3. Rahman FB, et al. (2006) Uncompetitive inhibition of Xenopus laevis aldehyde dehydrogenase 1A1 by divalent cations. Zoolog Sci. 23(3): 239-44.
4. Jester JV, et al. (1999). The cellular basis of corneal transparency: evidence for “corneal crystallins”. J Cell Sci. 112 ( Pt 5): 613–22.