Anti-ALDH1A1 Antibody

Cat: 11388-RP02
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Anti-ALDH1A1 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-ALDH1A1 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human ALDH1A1
Immunogen
Recombinant Human ALDH1 protein (Catalog#11388-H07E)
Preparation
Produced in rabbits immunized with purified, recombinant Human ALDH1 (rh ALDH1; Catalog#11388-H07E; NP_000680.2; Ser 2-Ser 501). ALDH1 specific IgG was purified by human ALDH1 affinity chromatography .
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-ALDH1A1 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-ALDH1A1 Antibody Alternative Names
Anti-ALDC Antibody;Anti-ALDH-E1 Antibody;Anti-ALDH1 Antibody;Anti-ALDH11 Antibody;Anti-HEL-9 Antibody;Anti-HEL-S-53e Antibody;Anti-HEL12 Antibody;Anti-PUMB1 Antibody;Anti-RALDH1 Antibody
ALDH1A1 Background Information

Aldehyde dehydrogenase 1 family, member A1 (ALDH1A1), also known as Aldehyde dehydrogenase 1 (ALDH1), or Retinaldehyde Dehydrogenase 1 (RALDH1), is an enzyme that is expressed at high levels in stem cells and that has been suggested to regulate stem cell function. The retinaldehyde dehydrogenase (RALDH) subfamily of ALDHs, composed of ALDH1A1, ALDH1A2, ALDH1A3, and ALDH8A1, regulate development by catalyzing retinoic acid biosynthesis. The ALDH1A1 protein belongs to the aldehyde dehydrogenases family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. ALDH1A1 also belongs to the group of corneal crystallins that help maintain the transparency of the cornea. Increased ALDH1A1 activity has been found in the stem cell populations of leukemia and some solid tumors. In tumor specimens, increased ALDH1A1 immunopositivity was found not only in secretory type cancer epithelial cells but also in neuroendocrine tumor populations. ALDH1 has been identified as a reliable marker of breast cancer stem cells. ALDH1 expression in primary cancer is an independent prognostic factor in node-positive breast cancer patients. ALDH1A1 plays a key role in normal hematopoiesis, and as a TLX1 transcriptional target, ALDH1A1 may contribute to the ability of this homeoprotein to alter cell fate and induce tumor growth.

Full Name
aldehyde dehydrogenase 1 family, member A1
References
  • Li T, et al. (2010). ALDH1A1 is a marker for malignant prostate stem cells and predictor of prostate cancer patients' outcome. Lab Invest. 90(2): 234-44.
  • Levi BP, et al. (2009) Aldehyde dehydrogenase 1a1 is dispensable for stem cell function in the mouse hematopoietic and nervous systems. Blood. 113(8): 1670-80.
  • Rahman FB, et al. (2006) Uncompetitive inhibition of Xenopus laevis aldehyde dehydrogenase 1A1 by divalent cations. Zoolog Sci. 23(3): 239-44.
  • Jester JV, et al. (1999). The cellular basis of corneal transparency: evidence for corneal crystallins. J Cell Sci. 112 ( Pt 5): 613-22.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-ALDH1A1 Antibody (PE) Mouse Monoclonal FCM 11388-MM03-P
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    Anti-ALDH1A1 Antibody Mouse Monoclonal WB,ELISA,FCM,ICC/IF,IF 11388-MM03
    Anti-ALDH1A1 Antibody (FITC) Mouse Monoclonal FCM 11388-MM03-F
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