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ALDH1 / ALDH1A1 / ALDC Antibody, Rabbit PAb, Antigen Affinity Purified

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    Human ALDH1A1 Antibody Product Information
    Immunogen:Recombinant Human ALDH1 protein (Catalog#11388-H07E)
    Clone ID:
    Ig Type:Rabbit IgG
    Concentration:
    Formulation:0.2 μm filtered solution in PBS with 5% trehalose
    Preparation:Produced in rabbits immunized with purified, recombinant Human ALDH1 (rh ALDH1; Catalog#11388-H07E; NP_000680.2; Ser 2-Ser 501). ALDH1 specific IgG was purified by human ALDH1 affinity chromatography .
    Other ALDH1A1 Antibody Products
    Reactivity: Human  
    Application: FCM  
    • Slide 1
    11388-MM03-P-25
    11388-MM03-P-100
    25 Test 
    100 Tests 
    Add to Cart
    Reactivity: Human  
    Application: ELISA  
      11388-RP01-400
      11388-RP01-200
      11388-RP01-100
      400 µg 
      200 µg 
      100 µg 
      Add to Cart
      Reactivity: Human  
      Application: FCM  
      • Slide 1
      11388-MM03-F-25
      11388-MM03-F-100
      25 Test 
      100 Tests 
      Add to Cart
      Reactivity: Human  
      Application: ELISA  WB  FCM  IF  ICC/IF  
      • Slide 1
      • Slide 1
      • Slide 1
      11388-MM03-50
      11388-MM03-200
      11388-MM03-100
      50 µg 
      200 µg 
      100 µg 
      Add to Cart
      Reactivity: Human  
      Application: ELISA  IF  ICC/IF  
      • Slide 1
      11388-R023-50
      11388-R023-100
      50 µg 
      100 µg 
      Add to Cart
      ALDH1A1 / ALDH1 Background

      Aldehyde dehydrogenase 1 family, member A1 (ALDH1A1), also known as Aldehyde dehydrogenase 1 (ALDH1), or Retinaldehyde Dehydrogenase 1 (RALDH1), is an enzyme that is expressed at high levels in stem cells and that has been suggested to regulate stem cell function. The retinaldehyde dehydrogenase (RALDH) subfamily of ALDHs, composed of ALDH1A1, ALDH1A2, ALDH1A3, and ALDH8A1, regulate development by catalyzing retinoic acid biosynthesis. The ALDH1A1 protein belongs to the aldehyde dehydrogenases family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. ALDH1A1 also belongs to the group of corneal crystallins that help maintain the transparency of the cornea. Increased ALDH1A1 activity has been found in the stem cell populations of leukemia and some solid tumors. In tumor specimens, increased ALDH1A1 immunopositivity was found not only in secretory type cancer epithelial cells but also in neuroendocrine tumor populations. ALDH1 has been identified as a reliable marker of breast cancer stem cells. ALDH1 expression in primary cancer is an independent prognostic factor in node-positive breast cancer patients. ALDH1A1 plays a key role in normal hematopoiesis, and as a TLX1 transcriptional target, ALDH1A1 may contribute to the ability of this homeoprotein to alter cell fate and induce tumor growth.

      Human ALDH1A1 / ALDH1 References
    • Li T, et al. (2010). ALDH1A1 is a marker for malignant prostate stem cells and predictor of prostate cancer patients' outcome. Lab Invest. 90(2): 234-44.
    • Levi BP, et al. (2009) Aldehyde dehydrogenase 1a1 is dispensable for stem cell function in the mouse hematopoietic and nervous systems. Blood. 113(8): 1670-80.
    • Rahman FB, et al. (2006) Uncompetitive inhibition of Xenopus laevis aldehyde dehydrogenase 1A1 by divalent cations. Zoolog Sci. 23(3): 239-44.
    • Jester JV, et al. (1999). The cellular basis of corneal transparency: evidence for corneal crystallins. J Cell Sci. 112 ( Pt 5): 613-22.
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      Catalog: 11388-RP02-200
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      Datasheet & Documentation

      All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
      Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"