>Human Cell Expressed
>Rat ALCAM / CD166 Protein (His Tag)
|Catalog||Size (Price)||Quantity||In Stock||Operation||Other Information|
Activated leukocyte cell adhesion molecule Protein Datasheet
ALCAM / CD166 Protein Price Inquiry ( Available Sizes )
- ≥1mg Bulk: Inquiring Price
ALCAM / CD166 Protein Product Information
A DNA sequence encoding the rat ALCAM(O35112)(Met1-Lys527) was expressed, fused with a polyhistidine tag at the C-terminus.
|Expression Host:||Human Cells|
ALCAM / CD166 Protein QC Testing
|Purity:||> 98 % as determined by SDS-PAGE||SDS-PAGE:
ALCAM / CD166 protein
|Endotoxin:||< 1.0 EU per μg of the protein as determined by the LAL method|
|Stability:||Samples are stable for up to twelve months from date of receipt at -70℃|
|Predicted N terminal:||Trp 28|
The recombinant rat ALCAM comprises 511 amino acids and predicts a molecular mass of 57.5 kDa. The apparent molecular mass of the recombinant protein is approximately 68-91 kDa in SDS-PAGE under reducing conditions due to glycosylation.
|Formulation:||Lyophilized from sterile PBS, pH7.4.
ALCAM / CD166 Protein Usage Guide
|Storage:||Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.|
|Reconstitution:||A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.|
ALCAM / CD166 Protein Related Products & Topics
|Molecule||Species||Description //For Detailed Info. and Price------CLICK!||Cat. No|
|CD166/ALCAM||Human||CD166/ALCAM/Fc Protein, Recombinant||10045-H03H|
|CD166/ALCAM||Human||CD166/ALCAM Protein, Recombinant||10045-H08H|
|CD166/ALCAM||Mouse||CD166/ALCAM/Fc Protein, Recombinant||50005-M03H|
|CD166/ALCAM||Mouse||CD166/ALCAM Protein, Recombinant||50005-M08H|
|CD166/ALCAM||Rat||ALCAM / CD166 Protein, Recombinant||80221-R08H|
|Molecule||Application||Description //For Detailed Info. and Price------CLICK!||Cat. No|
|WB, ELISA||Rabbit Polyclonal Antibody||50005-RP01|
|WB, ELISA||CD166/ALCAM Antibody, Rabbit PAb (Antigen Affinity Purified)||50005-RP02|
|WB, ELISA||CD166/ALCAM Antibody, Mouse MAb||10045-MM05|
|WB, ELISA||CD166 / ALCAM Antibody||10045-RP01|
|WB, ELISA||CD166 / ALCAM Antibody (Antigen Affinity Purified)||10045-RP02|
ALCAM / CD166 Protein Description
ALCAM (activated leukocyte cell adhesion molecule) is a type I membrane glycoprotein and a member of the immunoglobulin superfamily. It is also known as CD166, MEMD, SC-1/DM-GRASP in the chicken, and KG-CAM in the rat. ALCAM / CD166 has five extracellular immunoglobulin-like domains which facilitates heterophilic (ALCAM-CD6) and homophilic (ALCAM-ALCAM) cell-cell interactions. While expressed in a wide variety of tissues and cells, ALCAM is restricted to subsets of cells usually involved in dynamic growth and / or migration processes. ALCAM is highly associated not only with embryonic hematopoiesis but also vasculoangiogenesis. ALCAM can bind itself homotypically and is also capable of binding CD6, NgCAM, and other unidentified brain proteins, and thus is Involved in neurite extension by neurons via heterophilic and homophilic manners. ALCAM / CD6 interaction plays a role in T cell development and T cell regulation, as well as in the binding of T- cells and B-cells to activated leukocytes. Further, ALCAM has also been observed to be upregulated on highly metastasizing melanoma cell lines, suggesting a role in tumor migration.
- Bowen, M. A. et al., 1995, J. Exp. Med. 181:2213-2220.
- Aruffo, A. et al., 1997, Immunol. Today. 18: 498-504.
- Degen, W. G. et al., 1998, Am. J. Pathol. 152: 805-813.
- Van, K. L. et al., 2001, J. Biol. Chem. 276: 25783-257890.
- Hirata, H. et al., 2006, Cells Tissues Organs. 184 (3-4):172-180.
- Jezierska, A. et al., 2006, Med Sci Monit.12 (7): BR245-256.