AKR1B1 Protein

Aldo-keto reductase family 1, member B1

AKR1B1 Products

AKR1B1 Protein, Recombinant

Molecule	Species	Description	Cat. No
AKR1B1	Human	AKR1B1 Protein, Recombinant	11294-H07E

AKR1B1 cDNA Clone

Molecule	Species	Description	Cat. No
AKR1B1	Human	AKR1B1 cDNA Clone / ORF Clone	HG11294-M

AKR1B1 Related Areas

Enzyme>>Oxidoreductase>> AKR1B1

AKR1B1 Alternative Names

ADR, ALDR1, ALR2, AR, MGC1804 [Homo sapiens]

AKR1B1 Background

Aldose reductase (AKR1B1) belongs to the aldo/keto reductase superfamily. AKR1B1 is a NADPH-dependent aldo-keto reductase best known as the rate-limiting enzyme of the polyol pathway. Expression of AKR1B1 was the highest in lens and retina. It is the first enzyme in the polyol pathway through which glucose is converted to sorbitol which is important for the function of various organs in the body, and has been implicated in the etiology of diabetic complications. AKR1B1 is quite abundant in the collecting tubule cells and thought to provide protection against hypertonic environment. Some human tissues contain AKR1B1 as well as AKR1B10, a closely related member of the aldo-keto reductase superfamily. 

AKR1B1 Related Studies

1. Huang SP, et al. (2010) Aldo-Keto Reductases in the Eye. Journal of Ophthalmology. 326 (3): 625-36.
2. Aida K, et al. (2000) Disruption of Aldose Reductase Gene (Akr1b1) Causes Defect in Urinary Concentrating Ability and Divalent Cation Homeostasis. Biochemical and Biophysical Research Communications.277 (2): 281-6.
3. Liao CS, et al. (2009) Regulation of AKR1B1 by thyroid hormone and its receptors. Molecular and Cellular Endocrinology. 307 (1-2): 109-17.
4. Baba SP, et al. (2009) Posttranslational glutathiolation of aldose reductase (AKR1B1): A possible mechanism of protein recovery from S-nitrosylation. Chemico-Biological Interactions. 178 (1-3): 250-8.