AK3L1 (Adenylate Kinase 4, AK4)

AK3L1 catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. AK3L1 may also be active with GTP.

AK3L1 (Adenylate Kinase 4, AK4) Related Areas

Enzyme>>Other>>AK4/AK3L1

AK3L1 (Adenylate Kinase 4, AK4) Alternative Names

AK4, AK3L1, RP4-686B20.1, AK3, AK3L2, MGC166959 [Homo sapiens]

Ak4, Ak3l1, RP23-301M3.3, Ak-3, Ak-4, Ak3, D4Ertd274e [Mus musculus]

Summaries for AK3L1 (Adenylate Kinase 4, AK4)

Entrez Gene summary for AK3L1:

This AK3L1 gene encodes a member of the adenylate kinase family of enzymes. AK3L1 is localized to the mitochondrial matrix. Adenylate kinases regulate the adenine and guanine nucleotide compositions within a cell by catalyzing the reversible transfer of phosphate group among these nucleotides. Five isozymes of adenylate kinase have been identified in vertebrates. Expression of these isozymes is tissue-specific and developmentally regulated. A pseudogene for this AK3L1 gene has been located on chromosome 17. Three transcript variants encoding the same protein have been identified for this gene. Sequence alignment suggests that the gene defined by NM_013410, NM_203464, and NM_001005353 is located on chromosome 1. [provided by RefSeq, Jul 2008]

OMIM - description for AK3L1:

Adenylate kinases (AKs), such as AK3L1, are a family of structurally and functionally related enzymes that catalyze a similar reaction, MgNTP + AMP = MgNDP + ADP (N = A or G). AKs are important for maintenance of homeostasis of the adenine and guanine nucleotide pools (Xu et al., 1992).

Wikipedia summary for AK3L1:

Adenylate kinase isoenzyme 4, mitochondrial is an enzyme that in humans is encoded by the AK3L1 gene.

Human AK3L1 (Adenylate Kinase 4, AK4) Protein General Information

 

• Protein names: Adenylate kinase isoenzyme 4, mitochondrial
• Sequence length: 223 AA.
• Catalytic activity: ATP + AMP = 2 ADP.
• Sequence similarities: AK3L1 belongs to the adenylate kinase family.
• Subunit structure: Monomer.
• Subcellular location: Mitochondrion matrix.

General information above from UniProt

Function for AK3L1 (Adenylate Kinase 4, AK4) Protein

UniProtKB:

AK3L1 catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. AK3L1 may also be active with GTP.