Anti-AK2 Antibody

Cat: 13146-R025
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Anti-AK2 Antibody (Rabbit Monoclonal antibody) General Information
Product name
Anti-AK2 Antibody
Validated applications
Species reactivity
Reacts with: Human
Human AK2
Recombinant Human AK2 protein (Catalog#13146-H20B)
This antibody was obtained from a rabbit immunized with purified, recombinant Human AK2 (rh AK2; Catalog#13146-H20B; P54819-1; Met1-Ile239).
Monoclonal Rabbit IgG Clone #025
Protein A
0.2 μm filtered solution in PBS
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-AK2 Antibody (Rabbit Monoclonal antibody) Validated Applications
Application Dilution Notes
WB 1:500-1:2000  
ELISA 1:5000-1:10000  
IHC-P 1:100-1:500  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-AK2 Antibody (Rabbit Monoclonal antibody) Images
Human AK2 / Adenylate kinase 2 Immunohistochemistry(IHC) 4726
Immunochemical staining of human AK2 in human liver with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections).
Human AK2 / Adenylate kinase 2 Immunohistochemistry(IHC) 4728
Immunochemical staining of human AK2 in human kidney with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections).
Human AK2 / Adenylate kinase 2 Western blot (WB) 6977

Anti-AK2 rabbit monoclonal antibody at 1:500 dilution

Lane A: Mouse kidney tissue lysate

Lane B: HCT116 Whole Cell Lysate

Lysates/proteins at 30 μg per lane.


Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution.

Developed using the Odyssey technique.

Performed under reducing conditions.

Predicted band size:26 kDa

Observed band size:26 kDa

Anti-AK2 Antibody Alternative Names
Anti-ADK2 Antibody;Anti-AK2 Antibody
AK2 Background Information

Adenylate kinase 2 (AK2) belongs to the Adenylate kinase family that contains three isozymes: AK1, AK2 and AK3. Adenylate kinases are involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate groups among adenine nucleotides. Adenylate kinase2 (AK2) is expressed in mitochondrial intermembrane space. It may play a role in apoptosis. It has been demonstrated that in apoptotic cells AK2 was translocated into the cytosol concomitantly with cytochronme C. Mutations in this gene are the cause of reticular dysgenesis. These mutations result in absent or strongly decreased protein expression. It has been also established that AK2 is specifically expressed in the stria vascularis region of the inner ear, which provides an explanation of the sensorineural deafness in these individuals. 

Full Name
adenylate kinase 2
  • Lagresle-Peyrou C, et al. (2008) Human adenylate kinase 2 deficiency causes a profound hematopoietic defect associated with sensorineural deafness. Nature Genetics. 41: 106-11.
  • Bruns GA, et al. (1977) Adenylate kinase 2, a mitochondrial enzyme. Biochem Genet. 15 (5-6): 477-86.
  • Khler C, et al. (1999) Release of adenylate kinase 2 from the mitochondrial intermembrane space during apoptosis. FEBS Lett. 447 (1): 10-2.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-AK2 Antibody Rabbit Polyclonal WB 13146-RP01
    Anti-AK2 Antibody Rabbit Monoclonal ICC/IF,IF 13146-R009
    Anti-AK2 Antibody Rabbit Polyclonal WB,ELISA,IHC-P,IP 13146-RP02
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