Anti-AK2 Antibody

Cat: 13146-RP02
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Anti-AK2 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-AK2 Antibody
Validated applications
Species reactivity
Reacts with: Human
Human AK2
Recombinant Human AK2 protein (Catalog#13146-H20B)
Produced in rabbits immunized with purified, recombinant Human AK2 (rh AK2; Catalog#13146-H20B; P54819-1; Met 1-Ile 239). AK2 specific IgG was purified by Human AK2 affinity chromatography.
Polyclonal Rabbit IgG
Protein A & Antigen Affinity
0.2 μm filtered solution in PBS
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-AK2 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
WB 1:500-1:2000  
ELISA 1:5000-1:10000  
IHC-P 1:500-1:2000  
IP 1-4 μL/mg of lysate  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-AK2 Antibody (Rabbit Polyclonal antibody) Images
Human AK2 / Adenylate kinase 2 Immunohistochemistry(IHC) 4725
Immunochemical staining of human AK2 in human liver with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections).
Human AK2 / Adenylate kinase 2 Immunohistochemistry(IHC) 4727
Immunochemical staining of human AK2 in human kidney with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections).
Human AK2 / Adenylate kinase 2 Western blot (WB) 13532

Anti-AK2 rabbit polyclonal antibody at 1:500 dilution

Lane A: Jurkat Whole Cell Lysate

Lysates/proteins at 30 μg per lane.


Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution.

Developed using the Odyssey technique.

Performed under reducing conditions.

Predicted band size:26 kDa

Observed band size:33 kDa

Human AK2 / Adenylate kinase 2 Immunoprecipitation(IP) 17708

AK2 was immunoprecipitated using:

Lane A:0.5 mg Jurkat Whole Cell Lysate

2 µL anti-AK2 rabbit polyclonal antibody and 15 μl of 50 % Protein G agarose.

Primary antibody:

Anti-AK2 rabbit polyclonal antibody,at 1:200 dilution

Secondary antibody:

Dylight 800-labeled antibody to rabbit IgG (H+L), at 1:5000 dilution

Developed using the odssey technique.

Performed under reducing conditions.

Predicted band size: 26 kDa

Observed band size: 26 kDa

Anti-AK2 Antibody Alternative Names
Anti-ADK2 Antibody;Anti-AK2 Antibody
AK2 Background Information

Adenylate kinase 2 (AK2) belongs to the Adenylate kinase family that contains three isozymes: AK1, AK2 and AK3. Adenylate kinases are involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate groups among adenine nucleotides. Adenylate kinase2 (AK2) is expressed in mitochondrial intermembrane space. It may play a role in apoptosis. It has been demonstrated that in apoptotic cells AK2 was translocated into the cytosol concomitantly with cytochronme C. Mutations in this gene are the cause of reticular dysgenesis. These mutations result in absent or strongly decreased protein expression. It has been also established that AK2 is specifically expressed in the stria vascularis region of the inner ear, which provides an explanation of the sensorineural deafness in these individuals. 

Full Name
adenylate kinase 2
  • Lagresle-Peyrou C, et al. (2008) Human adenylate kinase 2 deficiency causes a profound hematopoietic defect associated with sensorineural deafness. Nature Genetics. 41: 106-11.
  • Bruns GA, et al. (1977) Adenylate kinase 2, a mitochondrial enzyme. Biochem Genet. 15 (5-6): 477-86.
  • Khler C, et al. (1999) Release of adenylate kinase 2 from the mitochondrial intermembrane space during apoptosis. FEBS Lett. 447 (1): 10-2.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-AK2 Antibody Rabbit Polyclonal WB 13146-RP01
    Anti-AK2 Antibody Rabbit Monoclonal WB,ELISA,IHC-P 13146-R025
    Anti-AK2 Antibody Rabbit Monoclonal ICC/IF,IF 13146-R009
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