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AIMP1 / EMAP II / SCYE1 Antibody, Rabbit PAb, Antigen Affinity Purified

  • AIMP1 / EMAP II / SCYE1 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
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Human AIMP1/SCYE1 Antibody Product Information
Immunogen:Recombinant Human AIMP1 / EMAP II / SCYE1 protein (Catalog#10623-H07E)
Clone ID:
Ig Type:Rabbit IgG
Concentration:
Endotoxin:
Formulation:0.2 μm filtered solution in PBS with 5% trehalose
Preparation:Produced in rabbits immunized with purified, recombinant Human AIMP1 / EMAP II / SCYE1 (rh AIMP1 / EMAP II / SCYE1; Catalog#10623-H07E; NP_004748.2; Ala 2-Lys 312). AIMP1 / EMAP II / SCYE1 specific IgG was purified by Human AIMP1 / EMAP II / SCYE1 affinity chromatography.
Human AIMP1/SCYE1 Antibody IHC Application Image
AIMP1 / EMAP II / SCYE1 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
[Click to enlarge image]
Caption:
Immunochemical staining of human SCYE1 in human brain with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections).
Other AIMP1/SCYE1 Antibody Products
Reactivity: Human  
Application: 
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10623-T38-50
10623-T38-200
10623-T38-100
50 µg 
200 µg 
100 µg 
Add to Cart
Reactivity: Human  
Application: 
  • Slide 1
10623-MM05-50
10623-MM05-200
10623-MM05-100
50 µg 
200 µg 
100 µg 
Add to Cart
Reactivity: Mouse  
Application: ELISA  
    50697-RP01-400
    50697-RP01-200
    50697-RP01-100
    400 µg 
    200 µg 
    100 µg 
    Add to Cart
    Reactivity: Mouse  
    Application: ELISA  WB  IP  
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    50697-T52-50
    50697-T52-200
    50697-T52-100
    50 µg 
    200 µg 
    100 µg 
    Add to Cart
    AIMP1/EMAP II Background

    Aminoacyl tRNA synthase complex-interacting multifunctional protein 1, also known as Multisynthase complex auxiliary component p43, Endothelial monocyte-activating polypeptide II, AIMP1, EMAP2 and SCYE1, is a nucleus protein which contains one tRNA-binding domain. AIMP1 (also known as p43) is a factor associated with a macromolecular aminoacyl-tRNA synthetase (ARS) complex but also plays diverse regulatory roles in various physiological processes. AIMP1 negatively regulates TGF-beta signaling via stabilization of Smurf2. It suggests the novel activity of AIMP1 as a component of negative feedback loop of TGF-beta signaling. Recently, it been demonstrated that AIMP1 is also secreted and acts as a novel pleiotropic cytokine. AIMP1 protein induces the maturation and activation of DCs, which skew the immune response toward a Th1 response. AIMP1 is known as a cytokine working in the control of angiogenesis, inflammation, and wound healing. AIMP1 is secreted from the pancreas upon glucose starvation, and it also plays a glucagon-like role in glucose homeostasis. Although AIMP1 was identified as a component of the macromolecular aminoacyl tRNA synthetase complex involved in the cellular translation process, it was also found to be secreted as a cytokine having complex physiological functions. Among these, AIMP1's angiostatic and immune stimulating activities suggest its potential use as a novel antitumor therapeutic protein. AIMP1 may exert its antitumor activity by inducing tumor-suppressing cytokines. Thus, AIMP1 may be useful as a novel anti-tumor agent.

    Human AIMP1/EMAP II References
  • Lee YS, et al. (2006) Antitumor activity of the novel human cytokine AIMP1 in an in vivo tumor model. Mol Cells. 21(2): 213-7.
  • Park SG, et al. (2006) Hormonal activity of AIMP1/p43 for glucose homeostasis. Proc Natl Acad Sci U S A. 103(40): 14913-8.
  • Kim E, et al. (2008) AIMP1/p43 protein induces the maturation of bone marrow-derived dendritic cells with T helper type 1-polarizing ability. J Immunol. 180(5): 2894-902.
  • Lee YS, et al. (2008) AIMP1/p43 downregulates TGF-beta signaling via stabilization of smurf2. Biochem Biophys Res Commun. 371(3): 395-400.
  • Han JM, et al. (2010) Antitumor activity and pharmacokinetic properties of ARS-interacting multi-functional protein 1 (AIMP1/p43). Cancer Lett. 287(2): 157-64.
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    All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"