AIMP1 / EMAP II Protein

Aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 / Endothelial-Monocyte Activating Polypeptide II

AIMP1 / EMAP II Products

AIMP1 / EMAP II Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat No
AIMP1/EMAP II	Human	AIMP1/EMAP II Protein, Recombinant	10623-H07E

AIMP1 / EMAP II cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat No
AIMP1/EMAP II	Human	Homo sapiens AIMP1/EMAP II cDNA Clone	HG10623-M
AIMP1/EMAP II	Mouse	Mouse AIMP1/EMAP II cDNA gene Clone / ORF gene clone	MG50697-M

AIMP1 / EMAP II Related Areas

Cancer>>Angiogenesis>>Cytokines/Chemokines in Angiogenesis>>AIMP1/EMAP II

AIMP1 / EMAP II Alternative Names

AIMP1, EMAPII, EMAP2, SCYE1, p43 [Homo sapiens]

Aimp1, EMAPII, Emap2, Scye1, 9830137A06Rik, AIMP1/p43, p43 [Mus musculus]

AIMP1 / EMAP II Background

Aminoacyl tRNA synthase complex-interacting multifunctional protein 1, also known as Multisynthase complex auxiliary component p43, Endothelial monocyte-activating polypeptide II, AIMP1, EMAP2 and SCYE1, is a nucleus protein which contains one tRNA-binding domain. AIMP1 (also known as p43) is a factor associated with a macromolecular aminoacyl-tRNA synthetase (ARS) complex but also plays diverse regulatory roles in various physiological processes. AIMP1 negatively regulates TGF-beta signaling via stabilization of Smurf2. It suggests the novel activity of AIMP1 as a component of negative feedback loop of TGF-beta signaling. Recently, it been demonstrated that AIMP1 is also secreted and acts as a novel pleiotropic cytokine. AIMP1 protein induces the maturation and activation of DCs, which skew the immune response toward a Th1 response. AIMP1 is known as a cytokine working in the control of angiogenesis, inflammation, and wound healing. AIMP1 is secreted from the pancreas upon glucose starvation, and it also plays a glucagon-like role in glucose homeostasis. Although AIMP1 was identified as a component of the macromolecular aminoacyl tRNA synthetase complex involved in the cellular translation process, it was also found to be secreted as a cytokine having complex physiological functions. Among these, AIMP1's angiostatic and immune stimulating activities suggest its potential use as a novel antitumor therapeutic protein. AIMP1 may exert its antitumor activity by inducing tumor-suppressing cytokines. Thus, AIMP1 may be useful as a novel anti-tumor agent.

AIMP1 / EMAP II Related Studies

1. Lee YS, et al. (2006) Antitumor activity of the novel human cytokine AIMP1 in an in vivo tumor model. Mol Cells. 21(2): 213-7.
2. Park SG, et al. (2006) Hormonal activity of AIMP1/p43 for glucose homeostasis. Proc Natl Acad Sci U S A. 103(40): 14913-8.
3. Kim E, et al. (2008) AIMP1/p43 protein induces the maturation of bone marrow-derived dendritic cells with T helper type 1-polarizing ability. J Immunol. 180(5): 2894-902.
4. Lee YS, et al. (2008) AIMP1/p43 downregulates TGF-beta signaling via stabilization of smurf2. Biochem Biophys Res Commun. 371(3): 395-400.
5. Han JM, et al. (2010) Antitumor activity and pharmacokinetic properties of ARS-interacting multi-functional protein 1 (AIMP1/p43). Cancer Lett. 287(2): 157-64.