AIM2 Protein

Absent In Melanoma 2

AIM2 Products

AIM2 Protein, Recombinant

Molecule	Species	Description	Cat. No
AIM2	Human	AIM2 Protein, Recombinant, with GST Tag	11654-H09B

  11654-H09B: The ED₅₀ for this effect is typically 4-7 µg/ml. Measured by its ability to inhibit the proliferation of MCF7 human breast adenocarcinoma cells. （Karey, K.P. et al. (1988) Cancer Research 48:4083.）

AIM2 cDNA Clone

Molecule	Species	Description	Cat. No
AIM2	Human	Homo sapiens AIM2 cDNA Clone	HG11654-M

AIM2 Alternative Names

AIM2, RP11-520H16.3, PYHIN4 [Homo sapiens]

Aim2, Gm1313 [Mus musculus]

AIM2 Background

AIM2, Absent In Melanoma 2 is a member of the interferon-inducible HIN-200 protein family that contains an amino-terminal pyrin domain and a carboxy-terminal oligonucleotide/oligosaccharide-binding domain, senses cytoplasmic DNA by means of its oligonucleotide/oligosaccharide-binding domain and interacts with ASC (apoptosis-associated speck-like protein containing a CARD) through its pyrin domain to activate caspase-1. In response to foreign cytoplasmic DNA, AIM2 forms an inflammasome, resulting in caspase activation in inflammatory cells. It had been pointed to a role of AIM2 function in both inflammation and cancer. AIM-2 antigen is expressed in a wide variety of tumor types, including neuroectodermal tumors, as well as breast, ovarian and colon carcinomas. AIM-2 could be used as a tumor antigen target for monitoring vaccine trials or to develop antigen specific active immunotherapy for glioma patients.

AIM2 Related Studies

1. Patsos G, et al. (2010) Restoration of absent in melanoma 2 (AIM2) induces G2/M cell cycle arrest and promotes invasion of colorectal cancer cells. Int J Cancer. 126(8): 1838-49.
2. Fernandes-Alnemri T, et al. (2009) AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA. Nature. 458(7237): 509-13.
3. Chen IF, et al. (2006) AIM2 suppresses human breast cancer cell proliferation in vitro and mammary tumor growth in a mouse model. Mol Cancer Ther. 5(1): 1-7.
4. Liu G, et al. (2004) AIM-2: a novel tumor antigen is expressed and presented by human glioma cells. J Immunother. 27(3): 220-6.