AGRP Protein

Agouti Related Protein

AGRP Products

AGRP Protein, Recombinant

Molecule	Species	Description	Cat. No
AGRP/AGRT	Human	AGRP/Fc Protein, Recombinant	10070-H02H
AGRP/AGRT	Human	AGRP Protein, Recombinant	10070-H08H
AGRP/AGRT	Mouse	AGRP Protein, Recombinant	50276-M08H

AGRP cDNA Clone

Molecule	Species	Description	Cat. No
AGRP/AGRT	Human	Homo sapiens AGRP transcript variant 1 cDNA Clone(NM_001138.1)	HG10070-M
AGRP/AGRT	Mouse	Mus musculus AGRP cDNA Clone	MG50276-M

AGRP Alternative Names

AGRP, AGRT, ART, ASIP2, MGC118963 [Homo sapiens]

Agrp, Agrt, Art [Mus musculus]

AGRP Background

Agouti Related Protein (AGRP, or AGRT), is an endogenous antagonist of the melanocortin receptors MC3R and MC4R found in the hypothalamus and exhibits potent orexigenic activity. AGRP can act as a competitive antagonist to proopiomelanocortin (POMC)-derived peptides at the melanocortin-4 receptor (MC4R), and that this homeostatic mechanism is important as a means of coordinating appetite with perceived metabolic requirement. AGRP is upregulated by fasting while intracerebroventricular injections of synthetic AGRP lead to increased appetite and food intake. Thus, AGRP is a powerful orexigenic peptide that increases food intake when ubiquitously overexpressed or when administered centrally.

AGRP Related Studies

1. Ilnytska O, et al. (2008) The role of the Agouti-Related Protein in energy balance regulation. Cell Mol Life Sci. 65(17): 2721-31.
2. Pritchard LE, et al. (2005) Agouti-related protein: more than a melanocortin-4 receptor antagonist? Peptides. 26(10): 1759-70.
3. Stütz AM, et al. (2005) The agouti-related protein and its role in energy homeostasis. Peptides. 26(10): 1771-81.
4. Millhauser GL, et al. (2003) Loops and links: structural insights into the remarkable function of the agouti-related protein. Ann N Y Acad Sci. 994: 27-35.