AGO3 (Argonaute 3, EIF2C3)

Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.

AGO3 (Argonaute 3, EIF2C3) Related Areas

Signal Transduction>>Translational Regulator>>AGO3/EIF2C3

AGO3 (Argonaute 3, EIF2C3) Alternative Names

AGO3, EIF2C3, RP4-789D17.2, FLJ12765, MGC86946 [Homo sapiens]

Ago3, Eif2c3, RP23-113P22.6, AW048688, C130014L07Rik [Mus musculus]

Summaries for AGO3 (Argonaute 3, EIF2C3)

Entrez Gene summary for AGO3 (Argonaute 3, EIF2C3):

This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, contains a PAZ domain and a PIWI domain, and may play a role in short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a tandem cluster of closely related family members including argonaute 4 and eukaryotic translation initiation factor 2C, 1. Two transcript variants encoding distinct isoforms have been identified for this gene.

OMIM - description for AGO3 (Argonaute 3, EIF2C3):

Members of the argonaute protein family are involved in RNA silencing phenomena. Among their biologic roles are regulation of development and determination of stem cell character. These proteins are evolutionarily conserved from bacteria and plants to higher organisms. They contain an approximately 130-amino acid PAZ domain thought to be involved in protein-protein interactions and a C-terminal 300-amino acid PIWI domain. For a review of argonaute proteins, see Carmell et al. (2002).

Wikipedia summary for AGO3 (Argonaute 3, EIF2C3):

Eukaryotic translation initiation factor 2 subunit 3 is a protein that in humans is encoded by the EIF2S3 gene.

Human AGO3 (Argonaute 3, EIF2C3) Protein General Information

 

• Protein names: Recommended name: Protein argonaute-3 Short name=Argonaute3 Short name=hAgo3
• Sequence length: 860 AA.
• Sequence similarities: Belongs to the argonaute family. Ago subfamily. Contains 1 PAZ domain. Contains 1 Piwi domain.
• Subunit structure: Interacts with EIF4B, IMP8, PRMT5 and TNRC6B.
• Subcellular location: Cytoplasm › P-body

General information above from UniProt

Function for AGO3 (Argonaute 3, EIF2C3) Protein

UniProtKB:

Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.

Genatlas:

• AGO3 (Argonaute 3, EIF2C3) playing an important role in the eukaryotic peptide chain initiation process