Argonaute-2 (Protein|Antibody|cDNA Clone|ELISA Kit)

All Argonaute-2 reagents are produced in house and quality controlled, including 6 Argonaute-2 Antibody, 30 Argonaute-2 Gene, 2 Argonaute-2 IPKit, 2 Argonaute-2 Lysate, 2 Argonaute-2 Protein, 2 Argonaute-2 qPCR. All Argonaute-2 reagents are ready to use.

Recombinant Argonaute-2 proteins are expressed by Baculovirus-Insect Cells with fusion tags as N-His.

Argonaute-2antibodies are validated with different applications, which are ELISA, WB, ICC/IF, IF, IP, IHC-P.

Argonaute-2cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each Argonaute-2 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.

Argonaute-2 Protein (2)

Species

Argonaute-2 Protein, Human, Recombinant (His Tag)

11079-H07B

Expression host: Baculovirus-Insect Cells

Human AGO2/Argonaute 2/EIF2C2 Protein 9386

Argonaute-2 Protein, Mouse, Recombinant (His Tag)

50683-M07B

Expression host: Baculovirus-Insect Cells

Mouse AGO2/Argonaute 2/EIF2C2 Protein 11821
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Argonaute-2 Antibody (6)

Application Clonality
Host

Anti-Argonaute-2 Antibody

11079-RP01

Application: ELISA

Clonality: PAb

Anti-Argonaute-2 Antibody

11079-T36

Application: WB,IHC-P,IP

Clonality: PAb

Human AGO2/Argonaute 2/EIF2C2 Immunohistochemistry(IHC) 4737

Anti-Argonaute-2 Antibody

11079-T54

Application: WB,ELISA,ICC/IF,IF,IP

Clonality: PAb

Human Argonaute-2 Western blot (WB) 19157

Anti-Argonaute-2 Antibody

50683-R140

Application: ELISA

Clonality: MAb

Anti-Argonaute-2 Antibody

50683-R036

Application: IHC-P,IP

Clonality: MAb

Mouse AGO2/Argonaute 2/EIF2C2 Immunohistochemistry(IHC) 3396

Anti-Argonaute-2 Antibody

50683-RP02

Application: ELISA

Clonality: PAb

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Argonaute-2 cDNA Clone (30)

Mouse
Human

Argonaute-2 qPCR Primer (2)

Argonaute-2 IP Kit (2)

Argonaute-2 Lysate (2)

Argonaute 2 (AGO2), also known as Eukaryotic translation initiation factor 2C2 (EIF2C2), belongs to the Argonaute family, AGO subfamily, which is a component of the RNA-induced silencing complex (RISC) and mediates small interfering RNA (siRNA)-directed mRNA cleavage and microRNA translational suppression. AGO2 protein is the catalytic engine of mammalian RNAi. It contains a PIWI domain that is structurally related to RNases H and possibly shares with them a two-metal-ion catalysis mechanism. Human AGO2 was unable to cleave preformed RNA duplexes and exhibited weaker binding affinity for RNA duplexes compared with the single strand RNA. The enzyme exhibited greater RNase H activity in the presence of Mn2+ compared with Mg2+. Human AGO2 exhibited weaker binding affinities and reduced cleavage activities for antisense RNAs with either a 5'-terminal hydroxyl or abasic nucleotide. In mouse hematopoiesis, AGO2 controls early development of lymphoid and erythroid cells. AGO2 is a highly specialized member of the Argonaute family with an essential nonredundant Slicer-independent function within the mammalian miRNA pathway. AGO2 regulates dFMR1 expression, and the relationship between dFMR1 and AGO2 was defined by their physical interaction and co-regulation of downstream targets. AGO2 and dFMR1 are also connected through a regulatory relationship. AGO2 is a regulator of dFMR1 expression and have clarified an important developmental role for AGO2 in the nervous system and germ line that requires dFMR1 function. In addition, AGO2 is regulated at both the transcriptional and posttranslational level, and also implicate AGO2 and enhanced micro-RNA activity in the tumorigenic progression of breast cancer cell lines.

Protein
Antibody
Gene
qPCR
IPKit
Lysate
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