All Adenylosuccinate Lyase reagents are produced in house and quality controlled, including 5 Adenylosuccinate Lyase Antibody, 30 Adenylosuccinate Lyase Gene, 1 Adenylosuccinate Lyase IPKit, 1 Adenylosuccinate Lyase Protein, 2 Adenylosuccinate Lyase qPCR. All Adenylosuccinate Lyase reagents are ready to use.
Recombinant Adenylosuccinate Lyase proteins are expressed by E. coli with fusion tags as N-His.
Adenylosuccinate Lyaseantibodies are validated with different applications, which are ELISA, ICC/IF, IF, WB, IHC-P, IP.
Adenylosuccinate LyasecDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each Adenylosuccinate Lyase of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
Adenylosuccinate lyase, also known as adenylosuccinase, ADSL or ASL, is an enzyme implicated in the reaction of adenylosuccinat converting to AMP and fumarate as part of the purine nucleotide cycle. The two substates of adenylosuccinate lyase (ADSL) are dephosphorylated derivatives of SAICA ribotide (SAICAR) and adenylosuccinate (S-AMP), which catalyzes an important reaction in the de novo pathway of purine biosynthesis. ADSL catalyzes two distinct reactions in the synthesis of purine nucleotides, both of which involve the _-elimination of fumarate to produce either aminoimidazole carboxamide ribotide from SAICAR or AMP from S-AMP. The Adenylosuccinate lyase deficiency is a rare autosomal recessive metabolic disorder characterized by the present of SAICA riboside and succinyladenosine (S-Ado). ADSL defect in different patients is often caused by different mutations to the enzyme.