>ADAMTSL1 / PUNCTIN Protein (His Tag)
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ADAMTS-like 1 Protein Datasheet
ADAMTSL1 / PUNCTIN Protein Price Inquiry ( Available Sizes )
ADAMTSL1 / PUNCTIN Protein Product Information
ADAMTSL1, ADAMTSR1, C9orf94
A DNA sequence encoding the human ADAMTSL1 ( Met 1- His439) (Q8N6G6 -2) was expressed, with a C-terminal polyhistidine tag.
|Expression Host:||Baculovirus-Insect cells|
ADAMTSL1 / PUNCTIN Protein QC Testing
|Purity:||> 97 % as determined by SDS-PAGE||SDS-PAGE:
ADAMTSL1 / PUNCTIN protein
|Endotoxin:||< 1.0 EU per μg of the protein as determined by the LAL method|
|Stability:||Samples are stable for up to twelve months from date of receipt at -70℃|
|Predicted N terminal:||Ile 24|
The secreted recombinant human ADAMTSL1 consists of 421 amino acids and predicts a molecular mass of 47 KDa. The apparent molecular mass of the protein is approximately 48 Kda in SDS-PAGE under reducing conditions due to glycosylation.
|Formulation:||Lyophilized from sterile 20mM Tris, 500mM NaCl, pH7.4.
ADAMTSL1 / PUNCTIN Protein Usage Guide
|Storage:||Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.|
|Reconstitution:||A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.|
ADAMTSL1 / PUNCTIN Protein Related Products & Topics
ADAMTSL1 / PUNCTIN Protein Description
ADAMTSL1 is a secreted molecule. It is similar to the members of the ADAMTS protein family which is composed by matrix metalloproteinases. Both ADAMTS proteins and ADAM protein family contain a disintegrin and a metalloprotease domain. While ADAMTSL1 contains the domains found in members of the ADAMTS protein family with the exception of the pro-metalloprotease and the disintegrin-like domain typical of this family. ADAMTSL1 gene is expressed in adult skeletal muscle. ADAMTSL1 may play an important role in the extracellular matrix as it is deposited in the cell substratum in a punctate fashion and is excluded from focal contacts. a long alternatively spliced isoform of this protein have been identified with additional thrombospondin-like repeats, Ig-like modules, and a C-terminal PLAC domain. It has been reported that N-glycosylation and O-fucosylation modify the secretion of ADAMTSL1, and its absence can downregulation secretion of this protein.
- Hirohata S. et al., 2002, J Biol Chem. 277 (14): 12182-9.
- Wang LW. et al., 2007, J. Biol. Chem. 282 (23): 17024-31.
- Hall NG. et al., 2004, Matrix Biol. 22 (6): 501-10.