ADAM9

ADAM9 (A disintegrin and metallopeptidase domain 9, MDC9, meltrin gamma), is a type 1 transmembrane protein that has been associated with cancer development and metastases. ADAM9 is consistently overexpressed in various human cancers, and plays a role in tumorigenesis in mouse models. ADAM9 cleaves and releases a number of molecules with important roles in tumorigenesis and angiogenesis, such as EGF, FGFR2iiib, Tie-2, Flk-1, EphB4, CD40, VCAM-1, and VE-cadherin, and could represent a potential therapeutic target in tumors where it is highly expressed. ADAM9 belongs to a family of transmembrane, disintegrin-containing metalloproteinases involved in protein ectodomain shedding and cell-cell and cell-matrix interactions. ADAM9 adhesive domain plays a role in regulating the motility of cells by interaction with beta1 integrins and modulates MMP synthesis.

ADAM9 Related Areas

Enzyme>>Protease & Regulator>>Metalloprotease & Regulator>>ADAM / ADAMTS>>ADAM9

Cancer>>Angiogenesis>>ADAM / ADAMTS>>ADAM9

ADAM9 Alternative Names

ADAM9, CORD9, KIAA0021, MCMP, MDC9, Mltng [Homo sapiens]

Adam9, AU020942, MDC9, Mltng, mKIAA0021 [Mus musculus]

Summaries for ADAM9

Entrez Gene summary for ADAM9:

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by ADAM9 gene interacts with SH3 domain-containing proteins, binds mitotic arrest deficient 2 beta protein, and is also involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor. Several alternatively spliced transcript variants have been identified for ADAM9 gene. [provided by RefSeq, Jul 2010]

Wikipedia summary for ADAM9:

Disintegrin and metalloproteinase domain-containing protein 9 is an enzyme that in humans is encoded by the ADAM9 gene. ADAM9 gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by ADAM9 gene interacts with SH3 domain-containing proteins, binds mitotic arrest deficient 2 beta protein, and is also involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor. Two alternative splice variants have been identified, encoding distinct isoforms.

Human ADAM9 Protein General Information

 

• Protein names: Disintegrin and metalloproteinase domain-containing protein 9 , Short name=ADAM 9
• Sequence length: 819 AA.
• Domain: Signal Transmembrane Transmembrane helix
• Sequence similarities: Contains 1 disintegrin domain. Contains 1 EGF-like domain. Contains 1 peptidase M12B domain.
• Cofactor: Binds 1 zinc ion per subunit
• Subcellular location: Isoform 1: Cell membrane; Single-pass type I membrane protein Ref.3. Isoform 2: Secreted
• Tissue specificity: Widely expressed. Expressed in chondrocytes. Isoform 2 is highly expressed in liver and heart.
• Involvement in disease: Defects in ADAM9 are the cause of cone-rod dystrophy type 9 (CORD9) [MIM:612775]. An inherited retinal dystrophy characterized by retinal pigment deposits visible on fundus examination, predominantly in the macular region, and initial loss of cone photoreceptors followed by rod degeneration. This leads to decreased visual acuity and sensitivity in the central visual field, followed by loss of peripheral vision. Severe loss of vision occurs earlier than in retinitis pigmentosa.

General information above from UniProt

Function for ADAM9 Protein

UniProtKB:

ADAM9 probable is zinc protease. ADAM9 may mediate cell-cell or cell-matrix interactions. Isoform 2 of ADAM9 displays alpha-secretase activity for APP.

Genatlas:

• ADAM9 plays an important role in cell-cell fusion, intracellular signaling, and other cellular functions
• ADAM9 is involved in cell migration and invasion
• ADAM9 contributes to heart development
• ADAM9 functions as cell adhesion molecule via its disintegrin-cysteine-rich domain
• ADAM9 plays a role in regulating the motility of cells and modulating MMP synthesis
• ADAM9 plays important roles in pathological retinal neovascularization, and in the development of pathological vessels in the retina and choroid

Homology for human ADAM9

• homolog to murine Adam9 (86.3pc)
• homolog to rattus Adam9 (85.3pc)

Phenotype Information for ADAM9

• Gene/Locus: ADAM9, MDC9, MCMP, CORD9
• Phenotype: Cone-rod dystrophy 9

Phenotype Information for ADAM9 from OMIM (Online Mendelian Inheritance in Man)