All ADAM17 reagents are produced in house and quality controlled, including 2 ADAM17 Antibody, 20 ADAM17 Gene, 1 ADAM17 IPKit, 1 ADAM17 Lysate, 1 ADAM17 Protein, 3 ADAM17 qPCR. All ADAM17 reagents are ready to use.
Recombinant ADAM17 proteins are expressed by HEK293 Cells with fusion tags as C-His.
ADAM17antibodies are validated with different applications, which are IP, ELISA.
ADAM17cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each ADAM17 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
ADAM17 is a member of the ADAM protein family of disintegrins and metalloproteases. ADAM17 is ubiquitously expressed in the human colon, with increased activity in the colonic mucosa of patients with ulcerative colitis, a main form of inflammatory bowel disease. The expression of ADAM17 may be inhibited by ethanol. It is involved in the processing of tumor necrosis factor alpha (TNF-α) at the surface of the cell, and from within the intracellular membranes of the trans-Golgi network. ADAM17 also plays a role in the release of a diverse variety of membrane-anchored cytokines, cell adhesion molecules, receptors, ligands, and enzymes. ADAM17 may play a prominent role in the Notch signaling pathway, during the proteolytic release of the Notch intracellular domain (from the Notch1 receptor) that occurs following ligand binding.