ADAM15 Protein & Antibody

A Disintegrin and Metallopeptidase domain 15

ADAM15 Products

ADAM15 Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
ADAM15	Human	ADAM15 Protein, Recombinant	10517-H08H
ADAM15	Human	ADAM15 Protein, Recombinant	10517-H08S
ADAM15	Mouse	ADAM15 Protein, Recombinant	51001-M08H

ADAM15 Antibody

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human ADAM15	WB, ELISA	Rabbit Monoclonal Antibody	10517-R007
Human ADAM15	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	10517-RP01
Human ADAM15	WB, ELISA	Rabbit Polyclonal Antibody	10517-RP02
Human ADAM15	FCM	ADAM15 Antibody ( FITC )	10517-MM05-F
Human ADAM15	WB, ELISA	ADAM15 Antibody	10517-MM11
Mouse ADAM15	WB, ELISA	ADAM15 Antibody (Antigen Affinity Purified)	51001-RP02

ADAM15 Related Areas

Enzyme>>Protease & Regulator>>Metalloprotease & Regulator>>ADAM / ADAMTS>>ADAM15

Cancer>>Angiogenesis>>ADAM / ADAMTS>>ADAM15

ADAM15 Alternative Names

ADAM15, MDC15, RP11-540D14.1 [Homo sapiens]

Adam15, MDC15, metargidin [Mus musculus]

ADAM15 Related Products

Protein Products

Molecule	Species	Description //For Detailed Info. and Price------CLICK!
ADAM9	Mouse	ADAM9 Protein, Recombinant
ADAM12	Human	ADAM12 Protein, Recombinant

Antibody Products

Molecule	Application	Description //For Detailed Info. and Price------CLICK!
Human ADAM12	WB, ELISA	Mouse Monoclonal Antibody
Human ADAM12	ELISA	Rabbit Monoclonal Antibody
Human ADAM12	WB, ELISA	Rabbit Polyclonal Antibody
Human ADAM12	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)

cDNA Clone Products

Molecule	Species	Description //For Detailed Info. and Price------CLICK!
ADAM8/CD156	Human	Homo sapiens ADAM8/CD156 cDNA Clone(NM_001109.3)
ADAM9	Mouse	Mus musculus ADAM9 cDNA Clone
ADAM12	Human	Homo sapiens ADAM12 cDNA Clone
ADAMTS1	Human	Homo sapiens ADAMTS1 cDNA Clone(NM_006988.3)
ADAMTS4	Human	Homo sapiens ADAMTS4 cDNA Clone(NM_005099.3)
ADAMTS5	Human	Homo sapiens ADAMTS5 cDNA Clone(NM_007038.3)

ADAM15 Background

ADAM15, also known as Metargidin, is a type I transmembrane glycoprotein belonging to the ADAM (A Disintegrin and Metalloprotease Domain) family of proteins and is widely expressed in different tissues and cell types. Members of this family contain an amino-terminal metalloprotease domain followed by a disintegrin domain, a cysteine-rich region and a membrane proximal EGF-like domain. The disintegrin domain of ADAM15/metargidin contains an RGD tripeptide sequence, suggesting that it may potentially interact with the integrin family of proteins. ADAM15 is a transmembrane multi-domain proteins implicated in proteolysis, cell-cell and cell-matrix interactions in various disease conditions. There is also evidence supporting a role for ADAM15 in angiogenesis and angioinvasion of tumor cells, which are critical for unrestrained tumor growth and metastatic spread. Given its diverse functions, ADAM15 may represent a pivotal regulatory component of tumor progression, an important target for therapeutic intervention, or emerge as a biomarker of disease progression.

ADAM15 Related Studies

1. Poghosyan Z, et al. (2002) Phosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinases. J Biol Chem. 277(7): 4999-5007.
2. Carl-McGrath S, et al. (2005) The disintegrin-metalloproteinases ADAM9, ADAM12, and ADAM15 are upregulated in gastric cancer. Int J Oncol. 26(1): 17-24.
3. Najy AJ, et al. (2008) ADAM15 supports prostate cancer metastasis by modulating tumor cell-endothelial cell interaction. Cancer Res. 68(4): 1092-9.
4. Maretzky T, et al. (2009) Characterization of the catalytic activity of the membrane-anchored metalloproteinase ADAM15 in cell-based assays. Biochem J. 420(1): 105-13.