Gene Summary: Acylphosphatase can hydrolyze the phosphoenzyme intermediate of different membrane pumps, particularly the Ca2+/Mg2+-ATPase from sarcoplasmic reticulum of skeletal muscle. Two isoenzymes have been isolated, called muscle acylphosphatase and erythrocyte acylphosphatase on the basis of their tissue localization. This gene ACYP2 encodes the muscle-type isoform (MT). An increase of the MT isoform is associated with muscle differentiation. [provided by RefSeq, Jul 2008]General information above from NCBI
Catalytic activity: An acylphosphate + H(2)O = a carboxylate + phosphate.
Sequence similarity: Belongs to the acylphosphatase family. Contains 1 acylphosphatase-like domain.C
General information above from UniProt
Degl'Innocenti,D. et al., 2004, IUBMB Life. 56 (1):29-33.
Gribenko A.V., et al., 2009, Proc. Natl. Acad. Sci. USA.106:2601-2606.
Yeung R.C., et al., 2006, Acta Crystallogr. F 62:80-82.
Burkard T.R., et al., 2011, BMC Syst. Biol. 5:17-17.
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