ACVRL1 Protein

Activin A receptor, type II-like 1

ACVRL1 Protein & Antibody

ACVRL1 Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
ACVRL1/ALK-1	Human	ACVRL1/Fc Protein, Recombinant	10066-H02H
ACVRL1/ALK-1	Human	ACVRL1 Protein, Recombinant	10066-H08H
ACVRL1/ALK-1	Mouse	ACVRL1/Fc Protein, Recombinant	50208-M03H
ACVRL1/ALK-1	Rat	ACVRL1/Fc Protein, Recombinant	10596-R03H
ACVRL1/ALK-1	Cynomolgus	ALK-1 / ACVRL1 Protein, Recombinant	90060-C02H

ACVRL1 cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
ACVRL1/ALK-1	Mouse	Mus musculus ACVRL1 cDNA Clone	MG50208-M
ACVRL1/ALK-1	Canine	Canine ACVRL1 Gene cDNA Clone / ORF Clone	DG70049-G
ACVRL1	Rat	Rat ACVRL1 cDNA Clone	RG80132-G

All ACVRL1 Protein and Antibody

ACVRL1 Alternative Names

ACVRL1, ALK-1, ALK1, ACVRLK1, HHT, HHT2, ORW2, SKR3, TSR-I [ Homo sapiens ]

ACVRL1, ALK-1, ALK1, ACVRLK1, AI115505, AI427544 [ Mus musculus ]

ACVRL1, R3; R-3, SETHKIR, MGC91691 [ Rattus norvegicus ]

ACVRL1 Related Areas

Neuroscience>>Axon Guidance>>TGF-beta Family>>ACVRL1/ALK-1

Cancer>>Growth Factor & Receptor>>TGF-beta Superfamily>>Activin/Inhibitin>>ACVRL1/ALK-1

Cancer>>Growth Factor & Receptor>>TGF-beta Superfamily>>TGF-beta Family>>ACVRL1/ALK-1

Immunology>>Cytokine & Receptor>>TGF-beta Superfamily>>TGF-beta Superfamily Receptors>>ACVRL1/ALK-1

ACVRL1 Protein Related Products

Protein Products

Molecule	Species	Description //For Detailed Info. and Price------CLICK!
TGF-beta 1	Human	Latent TGFβ1 Protein, Recombinant
TGFBR2	Human	TGFBR2/Fc Protein, Recombinant
Decorin	Human	Decorin/Fc Protein, Recombinant
Decorin	Human	Decorin Protein, Recombinant

Antibody Products

Molecule	Species	Description //For Detailed Info. and Price------CLICK!
Human TGF-beta 1	WB	Mouse Monoclonal Antibody
Human TGF-beta 1	ELISA	Mouse Monoclonal Antibody
Human TGF-beta 1	WB, ELISA	Rabbit Polyclonal Antibody
Human TGF-beta 1	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)

cDNA Clone Products

Molecule	Species	Description //For Detailed Info. and Price------CLICK!
TGF-beta 1	Human	Homo sapiens TGF-beta 1 cDNA Clone(NM_000660.3)
TGF-beta 2	Human	Homo sapiens TGF-beta 2 transcript variant 2 cDNA Clone(NM_003238.2)
TGF-beta 2	Mouse	Mus musculus TGF-beta 2 cDNA Clone
TGF-beta 3	Human	Homo sapiens TGF-beta 3 cDNA Clone
TGF-beta 3	Mouse	Mus musculus TGF-beta 3 cDNA Clone
ALK-1	Human	Homo sapiens ALK-1/ACVRL1 transcript variant 1 cDNA Clone(NM_000020.2)
ALK-7	Human	Homo sapiens ALK-7 cDNA Clone(NM_145259.2)
TGFBR1/ACVRLK4	Human	Homo sapiens TGFBR1/ACVRLK4 cDNA Clone(NM_004612.2)
TGFBR2	Human	Homo sapiens TGFBR2 transcript variant 2 cDNA Clone(NM_003242.5)
BAMBI/NMA	Human	Homo sapiens BAMBI/NMA cDNA Clone(NM_012342.2)
Decorin	Human	Homo sapiens Decorin transcript variant A1 cDNA Clone(NM_001920.3)
Smad1	Human	Homo sapiens Smad1 cDNA Clone(NM_001003688.1)
Smad2	Human	Homo sapiens SMAD2 transcript variant 2 cDNA Clone(NM_001003652.2)
Smad3	Human	Homo sapiens Smad3 cDNA Clone(NM_005902.3)

ACVRL1 Background

Activin A receptor, type II-like 1 (ACVRL1), also known as ALK-1 (activin receptor-like kinase 1), is an endothelial-specific type I receptor of the TGF-beta (transforming growth factor beta) receptor family of ligands. On ligand binding, a heteromeric receptor complex forms consisting of two type II and two type I transmembrane serine/threonine kinases. ACVRL1 protein is expressed in certain blood vessels of kidney, spleen, heart and intestine, serving as an important role during vascular development. Mutations in ACVRL1 gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2 and vascular disease.

ACVRL1 Related Studies

French Rendu-Osler network,et al. (2004) Molecular screening of ALK1/ACVRL1 and ENG genes in hereditary hemorrhagic telangiectasia in France. Hum Mutat. 23(4): 289-299.
Simon M, et al. (2006) Association of a polymorphism of the ACVRL1 gene with sporadic arteriovenous malformations of the central nervous system. J Neurosurg. 104(6): 945-9.
Argyriou L, et al. (2006) Novel mutations in the ENG and ACVRL1 genes causing hereditary hemorrhagic teleangiectasia. Int J Mol Med. 17(4):655-9.