ACVR2B Protein & Antibody (ACTRIIB)

Activin A Receptor, type IIB

ACVR2B Products

ACVR2B Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
ACVR2B/ACTRIIB	Human	ACVR2B/Fc Protein, Recombinant	10229-H02H
ACVR2B/ACTRIIB	Human	ACVR2B Protein, Recombinant	10229-H08H
ACVR2B/ACTRIIB	Mouse	ACVR2B/Fc Protein, Recombinant	50173-M03H
ACVR2B/ACTRIIB	Mouse	ACVR2B Protein, Recombinant	50173-M08H

10229-H02H: Approximately 11 ng/ml of recombinant human ActivinR-IIB/Fc Chimera will inhibit 50% of the biological response due to 4 ng/ml of myostatin. Measured by its dose-dependent blocking of myostatin inhibition on murine MPC-11 cell proliferation.

ACVR2B Antibody

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Mouse ACVR2B/ACTRIIB	WB, ELISA	ACVR2B/ACTRIIB Antibody, Rabbit Mab	50173-R105
Mouse ACVR2B/ACTRIIB	WB, ELISA	Rabbit Polyclonal Antibody	50173-RP01
Mouse ACVR2B/ACTRIIB	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	50173-RP02
Mouse ACVR2B/ACTRIIB	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	10486-RP02

ACVR2B cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
ACVR2B/ACTRIIB	Human	ACVR2B cDNA Clone / ORF Clone	HG10229-M
ACVR2B/ACTRIIB	Mouse	ACVR2B cDNA Clone / ORF Clone	MG50173-M
ACVR2B/ACTRIIB	Cynomolgus	ACVR2B cDNA Clone / ORF Clone	CG90056-G

ACVR2B Alternative Names

ACVR2B, ACTRIIB, ActR-IIB, MGC116908 [Homo sapiens]

Acvr2b, ActRIIB, MGC118477 [Mus musculus]

ACVR2B Related Areas

Cancer>>Growth Factor & Receptor>>TGF-beta Superfamily>>Activin/Inhibitin>>ACVR2B/ACTRIIB

Immunology>>Cytokine & Receptor>>TGF-beta Superfamily>>TGF-beta Superfamily Receptors>>ACVR2B/ACTRIIB

ACVR2B Related Products

Protein Products
Molecule	Species	Description //For Detailed Info. and Price------CLICK!
Inhibin beta A/INHBA	Human	Inhibin beta A/INHBA Protein, Recombinant
Inhibin beta B/INHBB	Human	Inhibin beta B/INHBB Protein, Recombinant
ALK-2/ACVR1	Human	ALK-2/ACVR1/Fc Protein, Recombinant
ALK-2/ACVR1	Mouse	ALK-2/ACVR1/Fc Protein, Recombinant
ACVR2A	Human	ACVR2A/Fc Protein, Recombinant
FSTL1/Follistatin Like 1	Human	FSTL1 Protein, Recombinant
FLRG/FSTL3	Mouse	FLRG/FSTL3 Protein, Recombinant

cDNA Clone Products
Molecule	Species	Description //For Detailed Info. and Price------CLICK!
Inhibin alpha/INHA	Human	Homo sapiens Inhibin alpha/INHA cDNA Clone(NM_002191.2)
Inhibin beta A/INHBA	Human	Homo sapiens Inhibin beta A/INHBA cDNA Clone(NM_002192.2)
Inhibin beta B/INHBB	Human	Homo sapiens Inhibin beta B/INHBB cDNA Clone(NM_002193.2)
Inhibin beta C/INHBC	Human	Homo sapiens Inhibin beta C/INHBC cDNA Clone(NM_005538.2)
Inhibin beta E/INHBE	Human	Homo sapiens Inhibin beta E/INHBE cDNA Clone(NM_031479.3)
ALK-2/ACVR1	Human	Homo sapiens ALK-2/ACVR1 transcript variant 2 cDNA Clone(NM_001111067.2)
ALK-4/ACVR1B	Human	Homo sapiens ALK-4/ACVR1B cDNA Clone(NM_004302.3)
ACVR2A	Human	Homo sapiens ACVR2A cDNA Clone(NM_001616.3)
Follistatin	Human	Homo sapiens Follistatin cDNA Clone(NM_013409.1)
FSTL1/Follistatin Like 1	Human	Homo sapiens FSTL1 cDNA Clone(NM_007085.4)

ACVR2B Background

ACVR2A and ACVR2B are two activin type II receptors. ACVR2B is integral to the activin and myostatin signaling pathway. Ligands such as activin and myostatin bind to ACVR2A and ACVR2B. Myostatin, a negative regulator of skeletal muscle growth, is regarded as a potential therapeutic target and binds to ACVR2B effectively, and to a lesser extent, to ACVR2A. The structure of human ACVR2B kinase domain in complex with adenine establishes the conserved bilobal architecture consistent with all other catalytic kinase domains. Haplotype structure at the ACVR2B and follistatin loci may contribute to interindividual variation in skeletal muscle mass and strength. Defects in ACVR2B are a cause of left-right axis malformations.

ACVR2B Related Studies

Kosaki R, et al. (1999) Left-right axis malformations associated with mutations in ACVR2B, the gene for human activin receptor type IIB. Am J Med Genet. 82(1):70-6.
Dupont S, et al. (2001) No evidence for linkage or for diabetes-associated mutations in the activin type 2B receptor gene (ACVR2B) in French patients with mature-onset diabetes of the young or type 2 diabetes. Diabetes 50(5):1219-21.
Albertson RC, et al. (2005) Zebrafish acvr2a and acvr2b exhibit distinct roles in craniofacial development. Developmental dynamics 233(4): 1405-18.
Walsh S, et al. (2007) Activin-type II receptor B (ACVR2B) and follistatin haplotype associations with muscle mass and strength in humans. J Appl Physiol. 102(6):2142-8.