Anti-ACVR2B Antibody

Cat: 50173-RP02
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Anti-ACVR2B Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-ACVR2B Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Mouse
Specificity
Mouse ACVR2B
Immunogen
Recombinant Mouse ACVR2B protein (Catalog#50173-M08H)
Preparation
Produced in rabbits immunized with purified, recombinant Mouse ACVR2B extracellular domain (rM ACVR2B; Catalog#50173-M08H; NP_031423.1; Met 1-Thr 134). ACVR2B specific IgG was purified by mouse ACVR2B affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-ACVR2B Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-ACVR2B Antibody Alternative Names
Anti-4930516B21Rik Antibody;Anti-ActRIIB Antibody
ACVR2B Background Information

ACVR2A and ACVR2B are two activin type II receptors. ACVR2B is integral to the activin and myostatin signaling pathway. Ligands such as activin and myostatin bind to ACVR2A and ACVR2B. Myostatin, a negative regulator of skeletal muscle growth, is regarded as a potential therapeutic target and binds to ACVR2B effectively, and to a lesser extent, to ACVR2A. The structure of human ACVR2B kinase domain in complex with adenine establishes the conserved bilobal architecture consistent with all other catalytic kinase domains. Haplotype structure at the ACVR2B and follistatin loci may contribute to interindividual variation in skeletal muscle mass and strength. Defects in ACVR2B are a cause of left-right axis malformations.

Full Name
activin A receptor, type IIB
References
  • Kosaki R, et al. (1999) Left-right axis malformations associated with mutations in ACVR2B, the gene for human activin receptor type IIB. Am J Med Genet. 82(1):70-6.
  • Dupont S, et al. (2001) No evidence for linkage or for diabetes-associated mutations in the activin type 2B receptor gene (ACVR2B) in French patients with mature-onset diabetes of the young or type 2 diabetes. Diabetes 50(5):1219-21.
  • Albertson RC, et al. (2005) Zebrafish acvr2a and acvr2b exhibit distinct roles in craniofacial development. Developmental dynamics 233(4): 1405-18.
  • Walsh S, et al. (2007) Activin-type II receptor B (ACVR2B) and follistatin haplotype associations with muscle mass and strength in humans. J Appl Physiol. 102(6):2142-8.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-ACVR2B Antibody Rabbit Monoclonal ELISA 50173-R307
    Anti-ACVR2B Antibody Rabbit Polyclonal WB,ELISA 50173-RP01
    Anti-ACVR2B Antibody Rabbit Monoclonal ELISA 50173-R105
    Anti-ACVR2B Antibody Rabbit Polyclonal ELISA 10229-RP01
    Anti-ACVR2B Antibody Rabbit Polyclonal ELISA,IHC-P 10229-T24
    Anti-ACVR2B Antibody Rabbit Monoclonal ELISA 10229-R037
    Anti-ACVR2B Antibody Rabbit Polyclonal ELISA,IP 10229-T20
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