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ACVR2B / ACTRIIB Antibody, Rabbit PAb, Antigen Affinity Purified

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    Mouse ACVR2B Antibody Product Information
    Immunogen:Recombinant Mouse ACVR2B protein (Catalog#50173-M08H)
    Clone ID:
    Ig Type:Rabbit IgG
    Concentration:
    Formulation:0.2 μm filtered solution in PBS with 5% trehalose
    Preparation:Produced in rabbits immunized with purified, recombinant Mouse ACVR2B extracellular domain (rM ACVR2B; Catalog#50173-M08H; NP_031423.1; Met 1-Thr 134). ACVR2B specific IgG was purified by mouse ACVR2B affinity chromatography.
    Other ACVR2B Antibody Products
    Reactivity: Human  
    Application: ELISA  
      10229-RP01-200
      10229-RP01-100
      10229-RP01-400
      200 µg 
      100 µg 
       
      Add to Cart
      Reactivity: Human  
      Application: ELISA  IP  
      • Slide 1
      10229-T20-200
      10229-T20-100
      10229-T20-50
      200 µg 
      100 µg 
      50 µg 
      Add to Cart
      Reactivity: Mouse  
      Application: ELISA  
        10229-R037-100
        10229-R037-50
        100 µg 
        50 µg 
        Add to Cart
        Reactivity: Mouse  
        Application: ELISA  WB  
        • Slide 1
        50173-RP01-100
        50173-RP01-200
        50173-RP01-400
        100 µg 
        200 µg 
         
        Add to Cart
        Reactivity: Mouse  
        Application: ELISA  
          50173-R105-50
          50173-R105-100
          50 µg 
          100 µg 
          Add to Cart
          Reactivity: Mouse  
          Application: ELISA  
            50173-R307-50
            50173-R307-100
            50 µg 
            100 µg 
            Add to Cart
            ACVR2B/Activin RIIB Background

            ACVR2A and ACVR2B are two activin type II receptors. ACVR2B is integral to the activin and myostatin signaling pathway. Ligands such as activin and myostatin bind to ACVR2A and ACVR2B. Myostatin, a negative regulator of skeletal muscle growth, is regarded as a potential therapeutic target and binds to ACVR2B effectively, and to a lesser extent, to ACVR2A. The structure of human ACVR2B kinase domain in complex with adenine establishes the conserved bilobal architecture consistent with all other catalytic kinase domains. Haplotype structure at the ACVR2B and follistatin loci may contribute to interindividual variation in skeletal muscle mass and strength. Defects in ACVR2B are a cause of left-right axis malformations.

            Mouse ACVR2B/Activin RIIB References
            1. Kosaki R, et al. (1999) Left-right axis malformations associated with mutations in ACVR2B, the gene for human activin receptor type IIB. Am J Med Genet. 82(1):70-6.
            2. Dupont S, et al. (2001) No evidence for linkage or for diabetes-associated mutations in the activin type 2B receptor gene (ACVR2B) in French patients with mature-onset diabetes of the young or type 2 diabetes. Diabetes 50(5):1219-21.
            3. Albertson RC, et al. (2005) Zebrafish acvr2a and acvr2b exhibit distinct roles in craniofacial development. Developmental dynamics 233(4): 1405-18.
            4. Walsh S, et al. (2007) Activin-type II receptor B (ACVR2B) and follistatin haplotype associations with muscle mass and strength in humans. J Appl Physiol. 102(6):2142-8.
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            Catalog: 50173-RP02-50
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            Datasheet & Documentation

            All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
            Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"