Anti-ACVR2B Antibody

Cat: 50173-RP01
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Anti-ACVR2B Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-ACVR2B Antibody
Validated applications
Species reactivity
Reacts with: Mouse
Mouse ACVR2B
Recombinant Mouse ACVR2B protein (Catalog#50173-M08H)
Produced in rabbits immunized with purified, recombinant Mouse ACVR2B extracellular domain (rM ACVR2B; Catalog#50173-M08H; NP_031423.1; Met 1-Thr 134). Total IgG was purified by Protein A affinity chromatography .
Polyclonal Rabbit IgG
Protein A
0.2 μm filtered solution in PBS with 5% trehalose
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-ACVR2B Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
WB 1:500-1:1000  
ELISA 1:5000-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-ACVR2B Antibody (Rabbit Polyclonal antibody) Images
Mouse ACVR2B/Activin RIIB Western blot (WB) 13653

Anti-ACVR2B rabbit polyclonal antibody at 1:500 dilution

Lane A: K562 Membrane Lysate

Lysates/proteins at 20 μg per lane.


Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution.

Developed using the Odyssey technique.

Performed under reducing conditions.

Predicted band size:58 kDa

Observed band size:62 kDa

Anti-ACVR2B Antibody Alternative Names
Anti-4930516B21Rik Antibody;Anti-ActRIIB Antibody
ACVR2B Background Information

ACVR2A and ACVR2B are two activin type II receptors. ACVR2B is integral to the activin and myostatin signaling pathway. Ligands such as activin and myostatin bind to ACVR2A and ACVR2B. Myostatin, a negative regulator of skeletal muscle growth, is regarded as a potential therapeutic target and binds to ACVR2B effectively, and to a lesser extent, to ACVR2A. The structure of human ACVR2B kinase domain in complex with adenine establishes the conserved bilobal architecture consistent with all other catalytic kinase domains. Haplotype structure at the ACVR2B and follistatin loci may contribute to interindividual variation in skeletal muscle mass and strength. Defects in ACVR2B are a cause of left-right axis malformations.

Full Name
activin A receptor, type IIB
  • Kosaki R, et al. (1999) Left-right axis malformations associated with mutations in ACVR2B, the gene for human activin receptor type IIB. Am J Med Genet. 82(1):70-6.
  • Dupont S, et al. (2001) No evidence for linkage or for diabetes-associated mutations in the activin type 2B receptor gene (ACVR2B) in French patients with mature-onset diabetes of the young or type 2 diabetes. Diabetes 50(5):1219-21.
  • Albertson RC, et al. (2005) Zebrafish acvr2a and acvr2b exhibit distinct roles in craniofacial development. Developmental dynamics 233(4): 1405-18.
  • Walsh S, et al. (2007) Activin-type II receptor B (ACVR2B) and follistatin haplotype associations with muscle mass and strength in humans. J Appl Physiol. 102(6):2142-8.
  • Product Description Host Clonality Application Catalog# (PDF)
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    Anti-ACVR2B Antibody Rabbit Polyclonal ELISA,IHC-P 10229-T24
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    Anti-ACVR2B Antibody Rabbit Polyclonal ELISA,IP 10229-T20
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