Cynomolgus ACVR1B / ALK-4 Protein (Fc Tag)
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Cynomolgus ACVR1B / ALK-4 Protein (Fc Tag) (Cytokine) PDF Download

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Activin A receptor, type IB Protein Datasheet


ACVR1B / ALK-4 Protein Price Inquiry ( Available Sizes )

ACVR1B / ALK-4 Protein Product Information

Synonym : ACVR1B
Protein Construction:

A DNA sequence encoding the cynomolgus ACVR1B(F7HNS7) (Met1-Glu126) was expressed, fused with the Fc region of human IgG1 at the C-terminus.

Source: Cynomolgus
Expression Host: Human Cells

ACVR1B / ALK-4 Protein QC Testing

Purity: > 85 % as determined by SDS-PAGE SDS-PAGE:

ACVR1B / ALK-4 protein

Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
Stability: Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal: Arg 27
Molecular Mass:

The recombinant cynomolgus ACVR1B is a disulfide-linked homodimer. The reduced monomer comprises 341 amino acids and has a calculated molecular mass of 38.2 KDa.The apparent molecular mass of it is approximately 44 KDa respectively in SDS-PAGE.

Formulation: Lyophilized from sterile PBS, pH7.4.
  1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
  2. Please contact us for any concerns or special requirements.

ACVR1B / ALK-4 Protein Usage Guide

Storage: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

ACVR1B / ALK-4 Protein Related Products & Topics

Related Areas:

Cancer>>Growth Factor & Receptor>>TGF-beta Superfamily>>Activin/Inhibitin>>ALK-4/ACVR1B

Immunology>>Cytokine & Receptor>>TGF-beta Superfamily>>TGF-beta Superfamily Receptors>>ALK-4/ACVR1B


Molecule Species Description //For Detailed Info. and Price------CLICK! Cat. No
ALK-4/ACVR1B Human ALK-4/ACVR1B/Fc Protein, Recombinant 10583-H03H
ALK-4/ACVR1B Human ALK-4/ACVR1B Protein, Recombinant 10583-H08H
ALK-4/ACVR1B Cynomolgus ACVR1B / ALK-4 Protein, Recombinant 90066-C02H


Molecule Application Description //For Detailed Info. and Price------CLICK! Cat. No
WB, ELISA ALK-4/ACVR1B Antibody, Mouse MAb 10583-MM01

ACVR1B / ALK-4 Protein Description

Activin receptor type-IB, also known as Serine/threonine-protein kinase receptor R2, Activin receptor-like kinase 4, ALK-4, and ACVRIB, is a single-pass type I  membrane protein which belongs to the protein kinase superfamily and TGFB receptor subfamily. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I  (I and IB) and two type I I (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with a cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. ALK-4 is expressed in many tissues, most strongly in kidney, pancreas, brain, lung, and liver. ALK4 and ALK7 can mediate signal transduction by Nodal proteins, although ALK7 appears to be a receptor more specifically dedicated to Nodal signaling.


  1. Reissmann E. et al., 2001, Genes Dev. 15 (15): 2010-22.
  2. Su GH. et al., 2001, Proc Natl Acad Sci . 98 (6): 3254-7.
  3. Inman GJ. et al., 2002, Mol. Pharmacol. 62 (1): 65-74.
  4. Harrison CA. et al., 2003, J. Biol. Chem. 278 (23): 21129-35.

All TGF-beta Proteins

Product name Product name
ACVR2B / ActivinR-IIB Protein ALK4 / ACVR1B Protein
ALK-2 / ACVR1 ProteinMouse GDF10 / BMP-3B Protein (Fc Tag)
ACVR2 / ACTRII / ACVR2A ProteinMouse Activin A Protein (His Tag)
BMP-2 ProteinTGFB2 / TGF-beta 2 Protein (Latent) (His Tag)
BMP-5 ProteinMouse TGFBR3 / Betaglycan Protein (His Tag)
BMPRIA / ALK-3 / CD292 ProteinATF2 Protein (GST Tag)
BMPR-II ProteinALK-2 / ACVR1 / ALK2 Protein (His Tag)
Endoglin / CD105 / ENG ProteinHuman / Rhesus / Canine TGFβ1 / TGFB1 Protein (Native)
TGFβR2 / TGFR2 ProteinRat TDGF1 / CRGF Protein
Mouse ALK-3 / BMPR1A ProteinBMPR1B / ALK6 (149-502) Protein (GST Tag)
Lefty A ProteinRat TGFBR2 Protein
Mouse ACVR2B ProteinCynomolgus ACVR1B / ALK-4 Protein
ACVR2B / ActivinR-IIB Protein (His Tag)Rat ALK-2 / ACVR1 / ALK2 Protein
BMPR-II Protein (His Tag)Cynomolgus TGFBR2 Protein
GDF-15 ProteinCynomolgus ALK-7 / ALK7 / ACVR1C Protein
Mouse ALK-2 / ACVR1 ProteinCynomolgus ALK-2 / ACVR1 / ALK2 Protein
Activin A Protein (His Tag)TGFBR1 / ALK-5 / SKR4 (aa 200-503) Protein (GST Tag)
latent TGFβ1 Protein (His Tag)Danio rerio (zebrafish) BMP-2 / BMP2A Protein (Native)
BMP-2 / BMP2A Protein (Native)Rat ACVR1B / ALK-4 Protein
Activin B Protein (His Tag)BMPR1B / ALK6 Protein
TGFB1 / TGF-beta1 Protein (Native)TGFBR3 / Betaglycan Protein (His Tag)
Mouse ACTRIIB / ACVR2B Protein (His Tag)Canine ALK-2 / ACVR1 / ALK2 Protein
ALK4 / ACVR1B Protein (His Tag)Canine ALK-2 / ACVR1 / ALK2 Protein (His Tag)
TGFBR1 / ALK-5 / SKR4 ProteinCanine GFRA1 / GFR alpha-1 Protein (His Tag)
Mouse ALK-3 / BMPR1A Protein (His Tag)Rat GFRA1 / GFR alpha-1 Protein
Endoglin / CD105 / ENG Protein (His Tag)Cynomolgus ACVR2B / ACTRIIB Protein (His Tag)
TDGF1 / CRGF Protein (His Tag)Rat NCAM1 / CD56 Protein (His Tag)
Mouse ACVR2A / ActrIIa Protein (His Tag)Mouse GFRA3 / GFR-alpha-3 Protein (His Tag)
Mouse ACVR2A / ActrIIa ProteinRat TDGF1 / CRGF Protein (His Tag)
Mouse Endoglin / ENG / CD105 Protein (His Tag)Cynomolgus ACVR2B / ACTRIIB Protein
Mouse MSTN / GDF8 ProteinRat TGFβ1 / TGFB1 Protein (His Tag)
ACVR2 / ACTRII / ACVR2A Protein (His Tag)Cynomolgus ACVR2B / ACTRIIB Protein
BMPRIA / ALK-3 / CD292 Protein (His Tag)Mouse TGFβ1 / TGFB1 Protein (His Tag)

All TGF-beta Antibodies

Product name Product name
BMPR2 / BMPR-II / PPH1 Antibody ALK-3 / BMPR-1A / CD292 Antibody (Antigen Affinity Purified)
BMPR2 / BMPR-II / PPH1 Antibody (Antigen Affinity Purified)Endoglin / CD105 / ENG Antibody
TGF-beta1 / TGFB1 AntibodyEndoglin / CD105 Antibody ( FITC )
TGF-beta1 / TGFB1 Antibody (Antigen Affinity Purified)Endoglin / CD105 Antibody ( FITC )
TGF-beta1 / TGFB1 Antibody (Mouse Monoclonal Antibody)Endoglin / CD105 / ENG Antibody
TGF-beta1 / TGFB1 AntibodyTGF-beta 1 Antibody
ACVR2B / ACTRIIB AntibodyBMP-2 Antibody
ACVR2B / ACTRIIB Antibody (Antigen Affinity Purified)Endoglin / CD105 Antibody
Endoglin / CD105 / ENG AntibodyACVR2B / ACTRIIB Antibody
Endoglin / CD105 / ENG Antibody (Antigen Affinity Purified)ACVR2A Antibody
ACVR1B / ALK4 AntibodyACVR2A Antibody (Antigen Affinity Purified)
Endoglin / ENG / CD105 AntibodyTGFBR3 Antibody
Endoglin / ENG / CD105 Antibody (Antigen Affinity Purified)TGFBR3 Antibody (Antigen Affinity Purified)
Endoglin / CD105 / ENG AntibodyALK-3 / BMPRIA Antibody
Endoglin / CD105 / ENG AntibodyBMP-7 Antibody
BMPR2 / BMPR-II / PPH1 AntibodyInhibin beta A / INHBA Antibody
ACVR2B / ACTRIIB AntibodyGFRA1 Antibody
ALK-3 / BMPR-1A / CD292 AntibodyTGFBR3 Antibody