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Rat ALK-2 / ACVR1 / ALK2 Protein (Fc Tag)
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Rat ALK-2 / ACVR1 / ALK2 Protein (Fc Tag) (Cytokine) PDF Download

Catalog   Size (Price) Quantity In Stock Operation
80118-R02H  
YES   
 

Protein Production & Purification Service | Recombinant Cytokines & Growth Factors

Activin A receptor, type IB Protein Datasheet

 

ALK-2 / ACVR1 / ALK2 Protein Price Inquiry ( Available Sizes )

ALK-2 / ACVR1 / ALK2 Protein Product Information

Synonym : ACVR1, Acvrlk2
Protein Construction:

A DNA sequence encoding the rat ACVR1 (P80201)(Met1-Glu123) was expressed, fused with the Fc region of human IgG1 at the C-terminus.

Source: Rat
Expression Host: Human Cells

ALK-2 / ACVR1 / ALK2 Protein QC Testing

Purity: > 90% as determined by SDS-PAGE SDS-PAGE:
SDS-PAGE

ALK-2 / ACVR1 / ALK2 protein

Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
Stability: Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal: Met 21
Molecular Mass:

The recombinant rat ACVR1/Fc is a disulfide-linked homodimer. The reduced monomer comprises 344 amino acids and has a predicted molecular mass of 38.5 kDa. The apparent molecular mass of the protein is approximately 43 kDa in SDS-PAGE under reducing conditions.

Formulation: Lyophilized from sterile PBS, pH7.4.
  1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
  2. Please contact us for any concerns or special requirements.

ALK-2 / ACVR1 / ALK2 Protein Usage Guide

Storage: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

ALK-2 / ACVR1 / ALK2 Protein Related Products & Topics

Related Areas:

Cancer>>Growth Factor & Receptor>>TGF-beta Superfamily>>Activin/Inhibitin>>ALK-2/ACVR1

Immunology>>Cytokine & Receptor>>TGF-beta Superfamily>>TGF-beta Superfamily Receptors>>ALK-2/ACVR1

Proteins:

Molecule Species Description //For Detailed Info. and Price------CLICK! Cat. No
ALK-2/ACVR1 Human ALK-2/ACVR1/Fc Protein, Recombinant 10227-H03H
ALK-2/ACVR1 Human ALK-2 / ACVR1 / ALK2 Protein, Recombinant 10227-H08B
ALK-2/ACVR1 Mouse ALK-2/ACVR1/Fc Protein, Recombinant 50297-M03H
ALK-2/ACVR1 Rat ALK-2 / ACVR1 / ALK2 Protein, Recombinant 80118-R02H
ALK-2/ACVR1 Cynomolgus ALK-2 / ACVR1 / ALK2 Protein, Recombinant 90058-C02H

Antibodies:

ALK-2 / ACVR1 / ALK2 Protein Description

Cytokines and hormones belonging to the transforming growth factor beta (TGFβ) superfamily such as the activin, anti-müllerian hormone (AMH), bone morphogenetic proteins (BMPs), and Nodal, are involved in a variety of physiological processes including growth, cell differentiation, homeostasis, osteogenesis, and apoptosis. They initiate signaling through heteromeric complexes of a type I  and a type I I serine/threonine kinase receptor. The two type receptors are type I transmembrane proteins and are distinguished by the presence of a glycine/serine-rich juxta-membrane domain found in the type I receptors. Type II receptors are required for binding ligands and recruitment of type I receptors which then form stable complexes, and type I receptors are essential for signaling transduction. ALK2, also termed as ACVR1, ActRI, SKR1, was initially identified as an activin type I receptor because of its ability to bind activin in concert with ActRII or IIB. In addition, ALK2 is also identified as a BMP type I receptor. ACVR1 has been demonstrated to form complex with either the BMP-2/7-bound BMPR-II or ACVR2A/ACVR2B and transduce signals to downstream components R-SMADs. Recombinant soluble ALK2 does not bind activin. Mutations in this gene are associated with fibrodysplasia ossificans progressive.

References

  1. Attisano L. et al., 1993, Cell. 75: 671-80.
  2. Ten Dijke P. et al., 1994, Science. 264: 101-4.
  3. Macias-Silva M. et al., 1998, J Biol Chem. 273: 25628-36.
  4. Shore EM. et al., 2006, Nature Genetics. 38: 525-7.
  5. Renlund N. et al., 2007, J Endocrinology. 195: 95-103.
 

All TGF-beta Proteins

Product name Product name
ACVR2B / ActivinR-IIB Protein ALK4 / ACVR1B Protein
ALK-2 / ACVR1 ProteinMouse GDF10 / BMP-3B Protein (Fc Tag)
ACVR2 / ACTRII / ACVR2A ProteinMouse Activin A Protein (His Tag)
BMP-2 ProteinTGFB2 / TGF-beta 2 Protein (Latent) (His Tag)
BMP-5 ProteinMouse TGFBR3 / Betaglycan Protein (His Tag)
BMPRIA / ALK-3 / CD292 ProteinATF2 Protein (GST Tag)
BMPR-II ProteinALK-2 / ACVR1 / ALK2 Protein (His Tag)
Endoglin / CD105 / ENG ProteinHuman / Rhesus / Canine TGFβ1 / TGFB1 Protein (Native)
TGFβR2 / TGFR2 ProteinRat TDGF1 / CRGF Protein
Mouse ALK-3 / BMPR1A ProteinBMPR1B / ALK6 (149-502) Protein (GST Tag)
Lefty A ProteinRat TGFBR2 Protein
Mouse ACVR2B ProteinCynomolgus ACVR1B / ALK-4 Protein
ACVR2B / ActivinR-IIB Protein (His Tag)Rat ALK-2 / ACVR1 / ALK2 Protein
BMPR-II Protein (His Tag)Cynomolgus TGFBR2 Protein
GDF-15 ProteinCynomolgus ALK-7 / ALK7 / ACVR1C Protein
Mouse ALK-2 / ACVR1 ProteinCynomolgus ALK-2 / ACVR1 / ALK2 Protein
Activin A Protein (His Tag)TGFBR1 / ALK-5 / SKR4 (aa 200-503) Protein (GST Tag)
latent TGFβ1 Protein (His Tag)Danio rerio (zebrafish) BMP-2 / BMP2A Protein (Native)
BMP-2 / BMP2A Protein (Native)Rat ACVR1B / ALK-4 Protein
Activin B Protein (His Tag)BMPR1B / ALK6 Protein
TGFB1 / TGF-beta1 Protein (Native)TGFBR3 / Betaglycan Protein (His Tag)
Mouse ACTRIIB / ACVR2B Protein (His Tag)Canine ALK-2 / ACVR1 / ALK2 Protein
ALK4 / ACVR1B Protein (His Tag)Canine ALK-2 / ACVR1 / ALK2 Protein (His Tag)
TGFBR1 / ALK-5 / SKR4 ProteinCanine GFRA1 / GFR alpha-1 Protein (His Tag)
Mouse ALK-3 / BMPR1A Protein (His Tag)Rat GFRA1 / GFR alpha-1 Protein
Endoglin / CD105 / ENG Protein (His Tag)Cynomolgus ACVR2B / ACTRIIB Protein (His Tag)
TDGF1 / CRGF Protein (His Tag)Rat NCAM1 / CD56 Protein (His Tag)
Mouse ACVR2A / ActrIIa Protein (His Tag)Mouse GFRA3 / GFR-alpha-3 Protein (His Tag)
Mouse ACVR2A / ActrIIa ProteinRat TDGF1 / CRGF Protein (His Tag)
Mouse Endoglin / ENG / CD105 Protein (His Tag)Cynomolgus ACVR2B / ACTRIIB Protein
Mouse MSTN / GDF8 ProteinRat TGFβ1 / TGFB1 Protein (His Tag)
ACVR2 / ACTRII / ACVR2A Protein (His Tag)Cynomolgus ACVR2B / ACTRIIB Protein
BMPRIA / ALK-3 / CD292 Protein (His Tag)Mouse TGFβ1 / TGFB1 Protein (His Tag)

All TGF-beta Antibodies

Product name Product name
BMPR2 / BMPR-II / PPH1 Antibody ALK-3 / BMPR-1A / CD292 Antibody (Antigen Affinity Purified)
BMPR2 / BMPR-II / PPH1 Antibody (Antigen Affinity Purified)Endoglin / CD105 / ENG Antibody
TGF-beta1 / TGFB1 AntibodyEndoglin / CD105 Antibody ( FITC )
TGF-beta1 / TGFB1 Antibody (Antigen Affinity Purified)Endoglin / CD105 Antibody ( FITC )
TGF-beta1 / TGFB1 Antibody (Mouse Monoclonal Antibody)Endoglin / CD105 / ENG Antibody
TGF-beta1 / TGFB1 AntibodyTGF-beta 1 Antibody
ACVR2B / ACTRIIB AntibodyBMP-2 Antibody
ACVR2B / ACTRIIB Antibody (Antigen Affinity Purified)Endoglin / CD105 Antibody
Endoglin / CD105 / ENG AntibodyACVR2B / ACTRIIB Antibody
Endoglin / CD105 / ENG Antibody (Antigen Affinity Purified)ACVR2A Antibody
ACVR1B / ALK4 AntibodyACVR2A Antibody (Antigen Affinity Purified)
Endoglin / ENG / CD105 AntibodyTGFBR3 Antibody
Endoglin / ENG / CD105 Antibody (Antigen Affinity Purified)TGFBR3 Antibody (Antigen Affinity Purified)
Endoglin / CD105 / ENG AntibodyALK-3 / BMPRIA Antibody
Endoglin / CD105 / ENG AntibodyBMP-7 Antibody
BMPR2 / BMPR-II / PPH1 AntibodyInhibin beta A / INHBA Antibody
ACVR2B / ACTRIIB AntibodyGFRA1 Antibody
ALK-3 / BMPR-1A / CD292 AntibodyTGFBR3 Antibody
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"